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1. (WO2012054717) DETECTING AND TREATING SOLID TUMORS THROUGH SELECTIVE DISRUPTION OF TUMOR VASCULATURE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/054717    International Application No.:    PCT/US2011/057086
Publication Date: 26.04.2012 International Filing Date: 20.10.2011
IPC:
A61K 9/127 (2006.01), A61K 47/48 (2006.01), A61K 49/18 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY [US/US]; 3400 N. Charles Street Baltimore, MD 21218 (US) (For All Designated States Except US).
VOGELSTEIN, Bert [US/US]; (US) (For US Only).
QIAO, Yuan [US/US]; (US) (For US Only).
HUANG, Xin [US/US]; (US) (For US Only).
KINZLER, Kenneth [US/US]; (US) (For US Only).
ZHOU, Shibin [US/US]; (US) (For US Only).
DIAZ, Luis [US/US]; (US) (For US Only)
Inventors: VOGELSTEIN, Bert; (US).
QIAO, Yuan; (US).
HUANG, Xin; (US).
KINZLER, Kenneth; (US).
ZHOU, Shibin; (US).
DIAZ, Luis; (US)
Agent: KAGAN, Sarah; 1100 13th St. N.W. Suite 1200 Washington, DC 20005-4051 (US)
Priority Data:
61/405,241 21.10.2010 US
Title (EN) DETECTING AND TREATING SOLID TUMORS THROUGH SELECTIVE DISRUPTION OF TUMOR VASCULATURE
(FR) DÉTECTION ET TRAITEMENT DE TUMEURS SOLIDES PAR DÉRÈGLEMENT SÉLECTIF DU SYSTÈME VASCULAIRE TUMORAL
Abstract: front page image
(EN)Several agents capable of inducing vascular responses akin to those observed in inflammatory processes enhance the accumulation of nanoparticles in tumors. Exemplary vascular-active agents include a bacterium, a pro-inflammatory cytokine, and microtubule-destabilizing drugs. Such agents can increase the tumor to blood ratio of radioactivity by more than 20-fold compared to nanoparticles alone. Moreover, vascular-active agents dramatically improved the therapeutic effect of nanoparticles containing radioactive isotopes or chemotherapeutic agents.
(FR)Cette invention concerne plusieurs agents pouvant induire des réponses vasculaires apparentées à celles observées dans les processus inflammatoires, lesdits agents favorisant l'accumulation de nanoparticules dans les tumeurs. Parmi ces agents actifs sur le plan vasculaire figurent une bactérie, une cytokine pro-inflammatoire et des médicaments déstabilisant les microtubules. Ces agents peuvent augmenter le rapport de radioactivité tumeur/sang de plus de 20 fois par rapport aux nanoparticules seules. Par ailleurs ces agents actifs sur le plan vasculaire améliorent considérablement l'effet thérapeutique de nanoparticules contenant des isotopes radioactifs ou des agents chimiothérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)