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1. (WO2012054509) DISCOVERY OF REGULATORY T CELLS PROGRAMMED TO SUPPRESS AN IMMUNE RESPONSE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/054509    International Application No.:    PCT/US2011/056746
Publication Date: 26.04.2012 International Filing Date: 18.10.2011
IPC:
C07K 14/54 (2006.01), A61K 38/20 (2006.01)
Applicants: DANA-FARBER CANCER INSTITUTE, INC. [US/US]; 450 Brookline Ave Boston, MA 02215 (US) (For All Designated States Except US).
CANTOR, Harvey [US/US]; (US) (For US Only).
KIM, Hye-Jung [KR/US]; (US) (For US Only).
LU, Linrong [CN/CN]; (CN) (For US Only)
Inventors: CANTOR, Harvey; (US).
KIM, Hye-Jung; (US).
LU, Linrong; (CN)
Agent: HOLLOWAY, Minita, G.; Wolf, Greenfield & Sacks, P.C. 600 Atlantic Avenue Boston, MA 02210-2206 (US)
Priority Data:
61/405,696 22.10.2010 US
Title (EN) DISCOVERY OF REGULATORY T CELLS PROGRAMMED TO SUPPRESS AN IMMUNE RESPONSE
(FR) DÉCOUVERTE DE LYMPHOCYTES T RÉGULATEURS PROGRAMMÉS POUR SUPPRIMER UNE RÉPONSE IMMUNITAIRE
Abstract: front page image
(EN)A method to treat an autoimmune disease is provided. The method involves administration of interleukin-15 receptor (IL-15R) agonists in an amount effective to ameliorate a symptom of the autoimmune disease. The invention also involves a method to treat an autoimmune disease by ex- vivo expansion of CD44+CD122+Kir+ CD8+ Treg cells and administration of the CD44+CD122+Kir+ CD8+ Treg cells. Compositions comprising CD44+CD122+Kir+ CD8+ Treg cells are also provided. Methods for stimulating an immune response to an antigen are also provided.
(FR)L'invention concerne une méthode de traitement d'une maladie auto-immune. La méthode met en jeu l'administration d'agonistes du récepteur de l'interleukine-15 (IL-15R) dans une quantité efficace pour améliorer un symptôme de la maladie auto-immune. L'invention concerne également une méthode de traitement d'une maladie auto-immune par l'expansion ex vivo de lymphocytes Treg CD44+CD122+Kir+CD8+ et l'administration des lymphocytes Treg CD44+CD122+Kir+CD8+. L'invention concerne également des compositions comprenant les lymphocytes Treg CD44+CD122+Kir+CD8+. L'invention concerne également des procédés de stimulation d'une réponse immunitaire vis-à-vis d'un antigène.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)