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1. (WO2012053758) PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING ALCOHOLIC LIVER DISEASES, CONTAINING CILOSTAZOL AS ACTIVE INGREDIENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/053758    International Application No.:    PCT/KR2011/007441
Publication Date: 26.04.2012 International Filing Date: 07.10.2011
IPC:
A61K 31/41 (2006.01), A61K 31/47 (2006.01), A61P 1/16 (2006.01), A61P 1/00 (2006.01)
Applicants: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YEUNGNAM UNIVERSITY [KR/KR]; 214-1 Dae-dong, Gyeongsan-si Gyeongsangbuk-do 712-160 (KR) (For All Designated States Except US).
KOREA HEALTH INDUSTRY DEVELOPMENT INSTITUTE(KHIDI) [KR/KR]; 187, Osongsaengmyeong 2-ro, Osong-eup Cheongwon-gun Chungcheongbuk-do 363-951 (KR) (For All Designated States Except US).
KIM, Jong-Yeon [KR/KR]; (KR) (For US Only).
EUN, Jong-Ryul [KR/KR]; (KR) (For US Only).
LEE, Youn-Ju [KR/KR]; (KR) (For US Only)
Inventors: KIM, Jong-Yeon; (KR).
EUN, Jong-Ryul; (KR).
LEE, Youn-Ju; (KR)
Agent: TAEBAEK INTELLECTUAL PROPERTY LAW FIRM; #906,Kolon technovalley, 60-4 Gasan-dong,Geumcheon-gu Seoul 153-770 (KR)
Priority Data:
10-2010-0103656 22.10.2010 KR
Title (EN) PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING ALCOHOLIC LIVER DISEASES, CONTAINING CILOSTAZOL AS ACTIVE INGREDIENT
(FR) COMPOSITION PHARMACEUTIQUE DESTINÉE AU TRAITEMENT OU À LA PRÉVENTION DE MALADIES DU FOIE PROVOQUÉES PAR L'ALCOOL, CONTENANT DU CILOSTAZOL EN TANT QUE PRINCIPE ACTIF
(KO) 실로스타졸을 유효성분으로 함유하는 알코올성 간질환 치료 또는 예방용 약학조성물
Abstract: front page image
(EN)The present invention relates to a pharmaceutical composition for treating or preventing alcoholic liver diseases, containing cilostazol as an active ingredient. Particularly, cilostazol concentration-dependently inhibits the expression level of TNF-α and the genes of fatty acid synthase (FAS) and significantly inhibits the activity of caspase-3, thereby showing superior effects in treating or preventing alcoholic liver diseases, particularly alcoholic hepatitis, compared to pentoxifylline, which had been used as a therapeutic agent for alcoholic hepatitis, and thus can be used as a drug for treating or preventing alcoholic hepatitis.
(FR)La présente invention concerne une composition pharmaceutique destinée au traitement ou à la prévention de maladies du foie provoquées par l'alcool, contenant du cilostazol en tant que principe actif. En particulier, le cilostazol inhibe, de manière dépendante de la concentration, le niveau d'expression de TNF-α et les gènes d'acide gras synthase (AGS), et inhibe sensiblement l'activité de la caspase-3. Ainsi, le cilostazol présente des effets supérieurs dans le traitement ou la prévention de maladies du foie provoquées par l'alcool (en particulier l'hépatite alcoolique) par rapport à la pentoxifylline ‑ qui avait été utilisée en tant qu'agent thérapeutique pour l'hépatite alcoolique ‑, et peut ainsi être utilisé en tant que médicament dans le traitement ou la prévention de l'hépatite alcoolique.
(KO)본 발명은 실로스타졸을 유효성분으로 함유하는 알코올성 간질환 치료 또는 예방용 약학조성물에 관한 것으로, 특히 상기 실로스타졸은 TNF-α 및 지방산 합성 효소인 FAS 유전자의 발현 수준을 농도의존적으로 억제할 뿐 아니라, 카스파제-3 활성을 유의적으로 억제함으로써 종래 알코올성 간염 치료제로 사용되어 오던 펜톡시필린보다 탁월한 알코올성 간질환, 특히 알코올성 간염 치료 또는 예방 효과를 나타내므로, 알코올성 간염 치료 또는 예방용 약제로서 유용하게 이용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)