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1. (WO2012053719) METHOD FOR INDUCING DIFFERENTIATION OF MESENCHYMAL STEM CELLS TO NERVE CELLS USING SONIC WAVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/053719    International Application No.:    PCT/KR2011/004191
Publication Date: 26.04.2012 International Filing Date: 08.06.2011
IPC:
C12N 13/00 (2006.01), C12N 5/0775 (2010.01), C12N 5/079 (2010.01)
Applicants: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR/KR]; 26, Pil-dong 3-ga, Jung-gu Seoul 100-715 (KR) (For All Designated States Except US).
PARK, Jung Keug [KR/KR]; (KR) (For US Only).
YOON, Moon Young [KR/KR]; (KR) (For US Only).
CHO, Hyun Jin [KR/KR]; (KR) (For US Only).
SEO, Young Kwon [KR/KR]; (KR) (For US Only).
JEON, Song Hee [KR/KR]; (KR) (For US Only).
YOON, Hee Hoon [KR/KR]; (KR) (For US Only)
Inventors: PARK, Jung Keug; (KR).
YOON, Moon Young; (KR).
CHO, Hyun Jin; (KR).
SEO, Young Kwon; (KR).
JEON, Song Hee; (KR).
YOON, Hee Hoon; (KR)
Agent: KIM, Soon Woong; 601 Ace Techno 5 cha 197-22 Guro-dong, Guro-gu Seoul 152-766 (KR)
Priority Data:
10-2010-0101652 19.10.2010 KR
Title (EN) METHOD FOR INDUCING DIFFERENTIATION OF MESENCHYMAL STEM CELLS TO NERVE CELLS USING SONIC WAVES
(FR) MÉTHODE POUR INDUIRE LA DIFFÉRENCIATION DE CELLULES SOUCHES MÉSENCHYMATEUSES EN CELLULES NERVEUSES À L'AIDE D'ONDES SONORES
(KO) 음파를 이용한 중간엽 줄기세포의 신경세포 분화유도 방법
Abstract: front page image
(EN)The present invention relates to a method for differentiation of mesenchymal stem cells. More specifically, the invention relates to a method for differentiating mesenchymal stem cells to nerve cells by treating the mesenchymal stem cells with low-frequency sonic waves. The differentiation method of the present invention can induce differentiation even with low-cost mediums rather than induced neural differentiation mediums which are expensive due to addition of growth factors, and the nerve cells differentiated according to the present invention may be useful for treatment of neurological brain diseases.
(FR)Cette invention concerne une méthode de différenciation de cellules souches mésenchymateuses. Plus spécifiquement, cette invention concerne une méthode de différenciation des cellules souches mésenchymateuses en cellules nerveuses par traitement des cellules souches mésenchymateuses avec des ondes sonores basse fréquence. La méthode de différenciation selon la présente invention peut induire la différenciation, même avec des milieux à bas coûts plutôt que les milieux de différenciation neuraux induits qui sont onéreux en raison de l'ajout de facteurs de croissance, et les cellules nerveuses différenciées selon la présente invention peuvent être utiles pour traiter les maladies neurologiques du cerveau.
(KO)본 발명은 중간엽 줄기세포의 분화 방법에 관한 것이다. 보다 구체적으로는, 저주파의 음파를 중간엽 줄기세포에 처리하여, 중간엽 줄기세포를 신경세포로 분화시키는 방법에 관한 것이다. 본 발명에 의한 분화방법은 성장인자 추가에 따른 고비용의 신경분화유도 배지가 아닌 저가의 배지에서도 분화를 유도할 수 있으며, 본 발명에 의해 분화된 신경세포는 뇌신경질환 치료에 유용하게 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)