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1. (WO2012052668) NOVEL BENZOTHIOPHENE DERIVATIVES WITH TNAP-INHIBITING ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/052668    International Application No.:    PCT/FR2011/052416
Publication Date: 26.04.2012 International Filing Date: 17.10.2011
IPC:
C07D 513/04 (2006.01), A61K 31/429 (2006.01), A61K 31/433 (2006.01), A61P 19/02 (2006.01)
Applicants: UNIVERSITE CLAUDE BERNARD LYON I [FR/FR]; 43 Boulevard du 11 Novembre 1918 F-69622 Villeurbanne Cedex (FR) (For All Designated States Except US).
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE [FR/FR]; 3 Rue Michel Ange F-75794 Paris Cedex 16 (FR) (For All Designated States Except US).
BUCHET, René [FR/FR]; (FR) (For US Only).
PELLET-ROSTAING, Stéphane [FR/FR]; (FR) (For US Only).
LEMAIRE, Marc [FR/FR]; (FR) (For US Only).
CHANG, lei [CN/FR]; (FR) (For US Only).
LI, Lina [CN/CN]; (CN) (For US Only).
MEBAREK, Saïda [FR/FR]; (FR) (For US Only).
POPOWYCZ, Florence [FR/FR]; (FR) (For US Only)
Inventors: BUCHET, René; (FR).
PELLET-ROSTAING, Stéphane; (FR).
LEMAIRE, Marc; (FR).
CHANG, lei; (FR).
LI, Lina; (CN).
MEBAREK, Saïda; (FR).
POPOWYCZ, Florence; (FR)
Agent: SARLIN, Laure; Cabinet Beau De Lomenie 51 Avenue Jean Jaures BP7073 F-69301 Lyon Cedex 07 (FR)
Priority Data:
1058542 19.10.2010 FR
Title (EN) NOVEL BENZOTHIOPHENE DERIVATIVES WITH TNAP-INHIBITING ACTIVITY
(FR) NOUVEAUX DERIVES DE BENZOTHIOPHENE, PRESENTANT UNE ACTIVITE INHIBITRICE DE LA TNAP
Abstract: front page image
(EN)The present invention relates to compounds of formula (I): in which R1, R2, R3, R4, R5, R6, X and Y are as defined in claim 1, to the use thereof as a medicament, and in particular for treating arthrosis or vascular calcifications, and also to the pharmaceutical compositions containing same, in combination with at least one pharmaceutically acceptable excipient.
(FR)La présente invention concerne des composés de formule (I) : dans laquelle R1, R2, R3, R4, R5, R6, X et Y sont tels que définis à la revendications 1, leur utilisation en tant que médicament, et notamment pour le traitement de l'arthrose ou de calcifications vasculaires, ainsi que les compositions pharmaceutiques les contenant en association avec au moins un excipient pharmaceutiquement acceptable.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)