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1. (WO2012051291) TARGETING ANTIGENS TO HUMAN DENDRITIC CELLS VIA DC-ASIALOGLYCOPROTEIN RECEPTOR TO PRODUCE IL-10 REGULATORY T CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/051291    International Application No.:    PCT/US2011/055956
Publication Date: 19.04.2012 International Filing Date: 12.10.2011
IPC:
A61K 39/385 (2006.01), A61K 39/02 (2006.01), A61K 39/35 (2006.01), A61K 39/002 (2006.01), A61K 39/12 (2006.01), A61P 37/00 (2006.01)
Applicants: BAYLOR RESEARCH INSTITUTE [US/US]; 3310 Live Oak Street, Suite 501 Dallas, Texas 75204 (US) (For All Designated States Except US).
OH, SangKon [KR/US]; (US) (For US Only).
LI, Dapeng [CN/US]; (US) (For US Only).
BANCHEREAU, Jacques F. [FR/US]; (US) (For US Only).
ZURAWSKI, Sandra [US/US]; (US) (For US Only).
ZURAWSKI, Gerard [AU/US]; (US) (For US Only)
Inventors: OH, SangKon; (US).
LI, Dapeng; (US).
BANCHEREAU, Jacques F.; (US).
ZURAWSKI, Sandra; (US).
ZURAWSKI, Gerard; (US)
Agent: FLORES, Edwin S.; Chalker Flores, LLP 14951 North Dallas Parkway, Suite 400 Dallas, Texas 75254 (US)
Priority Data:
61/392,910 13.10.2010 US
13/269,951 10.10.2011 US
Title (EN) TARGETING ANTIGENS TO HUMAN DENDRITIC CELLS VIA DC-ASIALOGLYCOPROTEIN RECEPTOR TO PRODUCE IL-10 REGULATORY T CELLS
(FR) CIBLAGE D'ANTIGÈNES À CELLULES DENDRITIQUES HUMAINES PAR RÉCEPTEUR DC-ASIALOGLYCOPROTÉINE POUR PRODUIRE DES LYMPHOCYTES T RÉGULATEURS IL-10
Abstract: front page image
(EN)Compositions and methods for targeting protein antigens to human DCs via DC-asialoglycoprotein receptor (DC-ASGPR) are disclosed herein. The DC-ASGPR carries an intracellular tyrosine-based and dileucine motif, resulting in the generation of such IL-10 Tregs both in vitro and in vivo. The methods of the present invention can be used for designing vaccines against autoimmune diseases where autoantigens are defined, such as type 1 diabetes and multiple sclerosis.
(FR)L'invention concerne des compositions et des procédés de ciblage d'antigènes protéiques à des cellules dendritiques (DC) humaines par l'intermédiaire du récepteur DC-asialoglycoprotéine (DC-ASGPR). Le DC-ASGPR porte un motif à base de tyrosine intracellulaire et dileucine, conduisant à la génération de tels Tregs IL-10, à la fois in vitro et in vivo. Les procédés de la présente invention peuvent être utilisés pour la conception de vaccins contre des maladies auto-immunes pour lesquelles des autoantigènes sont définis, tels que le diabète de type 1 et la sclérose en plaques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)