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Machine translation
1. (WO2012051139) NEW USES FOR SUBSTITUTED 2-AMINO-THIAZOLONES IN TREATING ALZHEIMER'S DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/051139    International Application No.:    PCT/US2011/055682
Publication Date: 19.04.2012 International Filing Date: 11.10.2011
IPC:
A61K 31/426 (2006.01), A61P 25/22 (2006.01), A61P 25/24 (2006.01), A61P 25/18 (2006.01), A61P 25/28 (2006.01)
Applicants: AMGEN INC. [US/US]; One Amgen Center Drive Thousand Oaks, CA 91320-1799 (US) (For All Designated States Except US).
WYSZYNSKI, Michael [US/US]; (US) (For US Only)
Inventors: WYSZYNSKI, Michael; (US)
Agent: PEET, Richard; Foley & Lardner LLP 3000 K Street Suite 600 Washington, DC 20007-5143 (US)
Priority Data:
61/393,445 15.10.2010 US
Title (EN) NEW USES FOR SUBSTITUTED 2-AMINO-THIAZOLONES IN TREATING ALZHEIMER'S DISEASE
(FR) NOUVELLES UTILISATIONS DE 2-AMINO-THIAZOLONES SUBSTITUÉES DANS TRAITEMENT DE LA MALADIE D'ALZHEIMER
Abstract: front page image
(EN)The invention provides 11-β -hydroxysteroid dehydrogenase type 1 enzyme (11βHSD1) inhibitors, such as a compound of the formula: (A). its hydroxy and keto metabolites, and pharmaceutically acceptable salts thereof, for treating cognitive disorders, including age-related cognitive isorders, such as Alzheimer's Disease. Also provided are methods and uses for inhibiting 11βHSD1 and for reducing the concentration or preventing the elevation of concentration of cortisol in the brain of a subject by administering the compound of the formula (A); its hydroxy and keto metabolites, and pharmaceutically acceptable salts thereof.
(FR)L'invention concerne des inhibiteurs de l'enzyme 11-β -hydroxystéroïde déshydrogénase de type 1 (11βHSD1), tels qu'un composé de la formule : (A), ses métabolites hydroxy et céto, et des sels de qualité pharmaceutique de ceux-ci, pour le traitement de troubles cognitifs, notamment des troubles cognitifs liés à l'âge, tels que la maladie d'Alzheimer. La présente invention concerne également des procédés et des utilisations pour l'inhibition de 11βHSD1 et pour la réduction de la concentration de cortisol ou la prévention de l'élévation de la concentration de cortisol dans le cerveau d'un sujet par l'administration du composé de la formule (A) ; ses métabolites hydroxy et céto, et des sels de qualité pharmaceutique de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)