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1. (WO2012050930) ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/050930    International Application No.:    PCT/US2011/053786
Publication Date: 19.04.2012 International Filing Date: 28.09.2011
Chapter 2 Demand Filed:    27.04.2012    
IPC:
C07K 14/00 (2006.01), A61K 38/22 (2006.01)
Applicants: AMYLIN PHARMACEUTICALS, LLC [US/US]; Attention: Intellectual Property Group 9360 Towne Centre Drive San Diego, CA 92121 (US) (For All Designated States Except US).
ASTRAZENECA PHARMACEUTICALS LP [--/US]; 1800 Concord Pike Wilmington, DE 19803 (US) (For All Designated States Except US).
ERICKSON, Mary [US/US]; (US) (For US Only).
LITZINGER, David, C. [US/US]; (US) (For US Only).
GHOSH, Soumitra, S. [US/US]; (US) (For US Only).
GUO, Zijian [US/US]; (US) (For US Only).
ROTH, Jonathan, David [US/US]; (US) (For US Only)
Inventors: ERICKSON, Mary; (US).
LITZINGER, David, C.; (US).
GHOSH, Soumitra, S.; (US).
GUO, Zijian; (US).
ROTH, Jonathan, David; (US)
Agent: KOERBER, Steven, C.; Kilpatrick Townsend & Stockton LLP Two Embarcadero Center, 8th Floor San Francisco, CA 94111 (US)
Priority Data:
61/422,091 10.12.2010 US
61/387,402 28.09.2010 US
Title (EN) ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION
(FR) POLYPEPTIDES TECHNIQUES DE DURÉE D'ACTION SUPÉRIEURE
Abstract: front page image
(EN)Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The compounds are engineered polypeptides which incorporate an albumin binding domain in combination with one or more biologically active polypeptides. Also provided are pharmaceutical compositions and methods of treatment for diseases and disorders including lipodystrophy, dyslipidemia, hyperlipidemia, overweight, obesity, hypothalamic amenorrhea, Alzheimer's disease, leptin deficiency, fatty liver disease or diabetes (including type I and type II). Additional diseases and disorders which can be treated by the compounds and methods described herein include nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD), metabolic syndrome X and Huntington's Disease.
(FR)La présente invention concerne des composés présentant entre autres une bonne durée d'action, une puissance d'action élevée et/ou un régime d'administration pratique, incluant une unique administration hebdomadaire. Les composés sont des polypeptides techniques incorporant un domaine de liaison de l'albumine combiné à un ou plusieurs polypeptides biologiquement actifs. La présente invention concerne également des compositions pharmaceutiques et des méthodes de traitement de maladies et de troubles dont : lipodystrophie, dyslipidémie, hyperlipidémie, surpoids, obésité, aménorrhée hypothalamique, maladie d'Alzheimer, carence en leptine, stéatose hépatique ou diabète (y compris de type I et de type II). Les maladies et troubles supplémentaires pouvant être traités par les composés et les méthodes selon l'invention incluent la stéato-hépatite non alcoolique (SHNA) et la stéatose hépatique non alcoolique (NAFLD), le syndrome métabolique X et la chorée de Huntington.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)