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Machine translation
1. (WO2012050893) IMMUNOGENIC POLYPEPTIDES HAVING AN IMMUNOGENIC SCAFFOLD PROTEIN AND A LOOP PEPTIDE, PRESENTING A 3074- OR 2219/2557- MONOCLONAL ANTIBODY-TARGETED EPITOPE, WHICH IS PRESENT IN THE HIV GP120 PROTEIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/050893    International Application No.:    PCT/US2011/053686
Publication Date: 19.04.2012 International Filing Date: 28.09.2011
IPC:
C07K 14/155 (2006.01), C12N 15/49 (2006.01), A61K 39/21 (2006.01)
Applicants: NEW YORK UNIVERSITY [US/US]; 70 Washington Square New York, NY 10012 (US) (For All Designated States Except US).
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY [US/US]; 65 Bergen Street Newark, NJ 07107 (US) (For All Designated States Except US).
MOLSOFT LLC [US/US]; 11199 Sorrento Valley Road, Suite 209 San Diego, CA 92121-1334 (US) (For All Designated States Except US).
UNIVERSITY OF MASSACHUSETTS [US/US]; One Beacon Street, 26th Floor Boston, MA 02108 (US) (For All Designated States Except US).
CARDOZO, Timothy [US/US]; (US) (For US Only).
KONG, Xiang-peng [US/US]; (US) (For US Only).
ZOLLA-PAZNER, Susan [US/US]; (US) (For US Only).
PINTER, Abraham [US/US]; (US) (For US Only).
KRACHMAROV, Chavdar [US/US]; (US) (For US Only).
LU, Shan [US/US]; (US) (For US Only).
WANG, Shixia [US/US]; (US) (For US Only).
TOTROV, Maxim [RU/US]; (US) (For US Only)
Inventors: CARDOZO, Timothy; (US).
KONG, Xiang-peng; (US).
ZOLLA-PAZNER, Susan; (US).
PINTER, Abraham; (US).
KRACHMAROV, Chavdar; (US).
LU, Shan; (US).
WANG, Shixia; (US).
TOTROV, Maxim; (US)
Agent: GOLDMAN, Michael, L.; LeClairRyan, A Professional Corporation 70 Linden Oaks, Suite 210 Rochester, NY 14625 (US)
Priority Data:
61/387,842 29.09.2010 US
Title (EN) IMMUNOGENIC POLYPEPTIDES HAVING AN IMMUNOGENIC SCAFFOLD PROTEIN AND A LOOP PEPTIDE, PRESENTING A 3074- OR 2219/2557- MONOCLONAL ANTIBODY-TARGETED EPITOPE, WHICH IS PRESENT IN THE HIV GP120 PROTEIN
(FR) POLYPEPTIDES IMMUNOGÈNES AYANT UNE PROTÉINE DE STRUCTURE IMMUNOGÈNE ET UN PEPTIDE DE BOUCLE, PRÉSENTANT UN ÉPITOPE CIBLÉ PAR UN ANTICORPS MONOCLONAL 3074 OU 2219/2557, QUI EST PRÉSENT DANS LA PROTÉINE GP120 DU VIH
Abstract: front page image
(EN)The present invention is directed to a recombinant immunogenic polypeptide. The polypeptide includes a loop peptide inserted into an immunogenic scaffold protein. The loop polypeptide has an amino acid sequence which presents the 3074 mAb- or the 2219/2557 mAb-targeted epitope of the HIV gpl20 protein and not other known epitopes of the HIV gpl20 protein. When used as an immunogen, the polypeptide induces an antibody response which neutralizes heterologous HIV-1 viruses in a pattern similar to that observed for the 3074 mAb- or the 2219/2557 mAb-targeted epitope, respectively. Pharmaceutical compositions containing the immunogenic polypeptide as well as methods of making and using it are also disclosed.
(FR)La présente invention concerne un polypeptide immunogène recombiné. Le polypeptide comprend un peptide de boucle inséré dans une protéine de structure immunogène. Le polypeptide de boucle comporte une séquence d'acides aminés qui présente l'épitope ciblé par l'Acm 3074 ou l'Acm 2219/2557 de la protéine gp120 du VIH et aucun autre épitope connu de la protéine gp120 du VIH. Lorsqu'il est utilisé comme immunogène, le polypeptide induit une réponse en anticorps qui neutralise les virus VIH-1 hétérologues selon un schéma similaire à celui observé pour l'épitope ciblé par l'Acm 3074 ou l'Acm 2219/2557, respectivement. L'invention concerne également des compositions pharmaceutiques contenant le polypeptide immunogène ainsi que des procédés pour les fabriquer et les utiliser.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)