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1. (WO2012050500) 1,2-DIHYDRO-4-HYDROXY-2-OXO-QUINOLINE-3-CARBOXANILIDES AS AHR ACTIVATORS.

Pub. No.:    WO/2012/050500    International Application No.:    PCT/SE2011/000179
Publication Date: Fri Apr 20 01:59:59 CEST 2012 International Filing Date: Wed Oct 12 01:59:59 CEST 2011
IPC: C07D 215/56
A61K 31/4365
A61K 31/4704
A61P 3/10
A61P 17/06
A61P 35/00
C07D 495/04
Applicants: IMMUNAHR AB
PETTERSSON, Lars
Inventors: PETTERSSON, Lars
Title: 1,2-DIHYDRO-4-HYDROXY-2-OXO-QUINOLINE-3-CARBOXANILIDES AS AHR ACTIVATORS.
Abstract:
The present invention relates to compounds which are 1, 2-dihydro-4- hydroxy-2-oxo-quinoline-3-carboxanilides, their thieno-pyridone analogs, and prodrugs thereof. This invention specifically relates to such derivatives containing an N-hydrogen in the carboxanilide moiety and which exhibit modulating activity towards the aromatic hydrocarbon receptor (AhR), and, specifically, also to prodrugs thereof. The present invention also relates to use of said compounds as a medicament, and for the treatment of cancer, autoimmune disorders and other disorders with an immunological component, and a pharmaceutical composition comprising one or more of said compounds and a method of treatment.