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1. (WO2012050193) EBOLA VIRUS LIPOSOME VACCINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/050193    International Application No.:    PCT/JP2011/073686
Publication Date: 19.04.2012 International Filing Date: 14.10.2011
IPC:
C07K 7/06 (2006.01), A61K 9/127 (2006.01), A61K 38/00 (2006.01), A61K 39/12 (2006.01), A61K 47/24 (2006.01), A61K 47/28 (2006.01), A61P 31/14 (2006.01), A61P 37/04 (2006.01), C12N 5/0783 (2010.01), C12N 7/04 (2006.01)
Applicants: SAITAMA MEDICAL UNIVERSITY [JP/JP]; 38, Morohongo, Moroyama-machi, Iruma-gun, Saitama 3500495 (JP) (For All Designated States Except US).
JAPAN AS REPRESENTED BY THE DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES [JP/JP]; 23-1, Toyama 1-chome, Shinjuku-ku, Tokyo 1628640 (JP) (For All Designated States Except US).
NOF CORPORATION [JP/JP]; 20-3, Ebisu 4-chome, Shibuya-ku, Tokyo 1506019 (JP) (For All Designated States Except US).
MATSUI, Masanori [JP/JP]; (JP) (For US Only).
UCHIDA, Tetsuya [JP/JP]; (JP) (For US Only).
TANEICHI, Maiko [JP/JP]; (JP) (For US Only).
MIKUMA, Ai [JP/JP]; (JP) (For US Only).
YOKOYAMA, Shoichi [JP/JP]; (JP) (For US Only)
Inventors: MATSUI, Masanori; (JP).
UCHIDA, Tetsuya; (JP).
TANEICHI, Maiko; (JP).
MIKUMA, Ai; (JP).
YOKOYAMA, Shoichi; (JP)
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410044 (JP)
Priority Data:
2010-231918 14.10.2010 JP
Title (EN) EBOLA VIRUS LIPOSOME VACCINE
(FR) VACCIN AU LIPOSOME CONTRE LE VIRUS ÉBOLA
(JA) エボラウイルスリポソームワクチン
Abstract: front page image
(EN)The present invention provides a peptide-bonded liposome that is a liposome to which a peptide is bonded, the peptide being an ebola virus antigen peptide that can induce cytolytic T lymphocytes restricted to HLA-A*0201 or HLA-A*2402, the liposome containing a liposome stabilization agent and a phospholipid having a acyl group having 14-24 carbon atoms and one unsaturated bond or a hydrocarbon group having 14-24 carbon atoms and one unsaturated bond, and the peptide being bonded to the surface of the liposome. Also, the present invention provides an ebola virus antigen peptide that can induce cytolytic T lymphocytes restricted to HLA-A*0201 or HLA-A*2402. The peptide-bonded liposome and the peptide are useful as an ebola virus vaccine or a cytolytic T lymphocyte activation agent.
(FR)L'invention concerne un liposome avec une liaison peptidique consistant en un liposome auquel est lié un peptide. Ledit peptide consiste en un peptide antigène du virus Ébola obtenu par dérivation d'un lymphocyte T cytotoxique restreint par HLA-A*0201 ou HLA-A*2402, comprend un phospholipide qui possède un groupe acyle de 14 à 24 atomes de carbone possédant une liaison insaturée, ou un groupe hydrocarbure de 14 à 24 atomes de carbone possédant une liaison insaturée, et est lié à la surface dudit liposome. Ainsi, l'invention concerne également le peptide antigène du virus Ébola obtenu par dérivation d'un lymphocyte T cytotoxique restreint par HLA-A*0201 ou HLA-A*2402. Le liposome à liaison peptidique, ou le peptide de l'invention se révèlent utiles en tant qu'activateur de lymphocyte T cytotoxique, et en tant que vaccin contre le virus Ébola.
(JA) 本発明は、ペプチドが結合したリポソームであって、 該ペプチドが、HLA-A*0201又はHLA-A*2402に拘束された細胞傷害性Tリンパ球を誘導し得るエボラウイルス抗原ペプチドであり; 該リポソームが、不飽和結合を1個有する炭素数14~24のアシル基又は不飽和結合を1個有する炭素数14~24の炭化水素基を有するリン脂質、及びリポソームの安定化剤を含有し;且つ 該リポソームの表面に該ペプチドが結合している、 ペプチド結合リポソームを提供する。 また、本発明は、HLA-A*0201又はHLA-A*2402に拘束された細胞傷害性Tリンパ球を誘導し得るエボラウイルス抗原ペプチドを提供する。 本発明のペプチド結合リポソームやペプチドは、細胞傷害性Tリンパ球活性化剤やエボラウイルスワクチンとして有用である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)