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Pub. No.:    WO/2012/050151    International Application No.:    PCT/JP2011/073489
Publication Date: 19.04.2012 International Filing Date: 13.10.2011
C07D 271/06 (2006.01), A61K 31/4245 (2006.01), A61P 1/18 (2006.01), A61P 3/00 (2006.01), A61P 3/04 (2006.01), A61P 3/06 (2006.01), A61P 3/10 (2006.01), A61P 7/10 (2006.01), A61P 9/04 (2006.01), A61P 9/10 (2006.01), A61P 9/12 (2006.01), A61P 13/12 (2006.01), A61P 19/06 (2006.01), A61P 25/00 (2006.01), A61P 27/12 (2006.01), A61P 31/00 (2006.01), A61P 43/00 (2006.01)
Applicants: DAIICHI SANKYO COMPANY,LIMITED [JP/JP]; 3-5-1,Nihonbashi Honcho,Chuo-ku, Tokyo 1038426 (JP) (For All Designated States Except US).
YAMANOI, Shigeo; (For US Only).
KATAGIRI, Takahiro; (For US Only).
HATTA, Madoka; (For US Only).
MATSUMOTO, Koji; (For US Only).
TAKAHASHI, Kanako; (For US Only).
YOSHITOMI, Tomomi; (For US Only).
OCHIAI, Yuichi; (For US Only)
Inventors: YAMANOI, Shigeo; .
KATAGIRI, Takahiro; .
HATTA, Madoka; .
TAKAHASHI, Kanako; .
YOSHITOMI, Tomomi; .
OCHIAI, Yuichi;
Agent: ISHIBASHI Koki; c/o DAIICHI SANKYO COMPANY, LIMITED, 1-2-58, Hiromachi,Shinagawa-ku Tokyo 1400005 (JP)
Priority Data:
2010-231471 14.10.2010 JP
2011-022325 04.02.2011 JP
(JA) アシルベンゼン誘導体
Abstract: front page image
(EN)Provided is a compound or a pharmaceutically acceptable salt thereof represented by general formula (I) which has an excellent blood glucose-lowering effect and protective effect on β cells or the pancreas, and also provided is a pharmaceutical composition having an excellent therapeutic and/or prophylactic effect against type 1 diabetes mellitus, type 2 diabetes mellitus, and other such diseases in which blood glucose rises in response to sugar metabolism anomalies.
(FR)L'invention porte sur un composé ou sur un sel de qualité pharmaceutique de celui-ci, représenté par la formule générale (I), qui présente un excellent effet réducteur de la glycémie, ainsi qu'un excellent effet protecteur des cellules β ou du pancréas. L'invention porte également sur une composition pharmaceutique ayant un excellent effet thérapeutique et/ou prophylactique contre le diabète sucré de type 1, le diabète sucré de type 2 et d'autres maladies telles que celles dans lesquelles la glycémie monte en réponse à des anomalies du métabolisme des sucres.
(JA)優れた血糖降下作用、β細胞もしくは膵臓の保護作用を有する化合物またはその薬学的に許容され得る塩、ならびに、糖代謝異常により血糖上昇を生ずる1型糖尿病、2型糖尿病などに対して優れた治療効果および/または予防効果を有する医薬組成物を提供すること。 一般式(I):で表される化合物またはその薬学的に許容され得る塩。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)