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1. (WO2012049688) AN IMPROVED PROCESS FOR THE PREPARATION OF RACEMIC 6, 6- DIMETHYL-3-AZABICYCLO-[3.1.0]-HEXANE AND ITS SALTS, A KEY RAW MATERIAL FOR HCV INHIBITOR.
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/049688    International Application No.:    PCT/IN2011/000428
Publication Date: 19.04.2012 International Filing Date: 28.06.2011
IPC:
C07D 209/52 (2006.01)
Applicants: ARCH PHARMALABS LIMITED [IN/IN]; "H" Wing, 4th Floor Tex Centre, off Saki Vihar Road Chandivali, Andheri (East) Mumbai 400 072 (IN) (For All Designated States Except US).
SHINDE, Anant Dharma [IN/IN]; (IN) (For All Designated States Except US).
CHAUDARI, Bapu Atmaram [IN/IN]; (IN) (For All Designated States Except US).
PAI, Ganesh Gurpur [IN/IN]; (IN) (For All Designated States Except US).
MANDAL, Arun Kanti [IN/IN]; (IN) (For All Designated States Except US).
RANBHAN, Kamlesh Jayantilal [IN/IN]; (IN) (For All Designated States Except US).
SONAANE, Sachin Ulhas [IN/IN]; (IN) (For All Designated States Except US).
SARJEKAR, Pushpalata Bakrishna [IN/IN]; (IN) (For All Designated States Except US)
Inventors: SHINDE, Anant Dharma; (IN).
CHAUDARI, Bapu Atmaram; (IN).
PAI, Ganesh Gurpur; (IN).
MANDAL, Arun Kanti; (IN).
RANBHAN, Kamlesh Jayantilal; (IN).
SONAANE, Sachin Ulhas; (IN).
SARJEKAR, Pushpalata Bakrishna; (IN)
Agent: SEHGAL, Dr., C. K. [IN/IN]; Arch Pharmalabs Limited Corporate R&D Centre, Plot No. 21 Midc-Taloja Navi Mumbai 410208 (IN)
Priority Data:
2833/MUM/2010 12.10.2010 IN
Title (EN) AN IMPROVED PROCESS FOR THE PREPARATION OF RACEMIC 6, 6- DIMETHYL-3-AZABICYCLO-[3.1.0]-HEXANE AND ITS SALTS, A KEY RAW MATERIAL FOR HCV INHIBITOR.
(FR) PROCÉDÉ AMÉLIORÉ POUR LA PRÉPARATION DE 6,6-DIMÉTHYL-3-AZABICYCLO-[3.1.0]HEXANE RACÉMIQUE ET DE SES SELS, UNE MATIÈRE PREMIÈRE CLEF POUR L'INHIBITEUR DE VHC
Abstract: front page image
(EN)The present invention discloses an efficient and economical process for the preparation of racemic 6, 6-dimethyl-3-azabicyclo-[3.1.0]-hexane of formula I and its salts. The invention relates to the compounds of formulae I and II. The compound of formula I is a key raw material for the preparation of a key intermediate (1R, 2S, 5S) - methyl 6,6-dimethyl -3-azabicyclo [3.1.0] hexane-2 carboxylic acid and ester and salts of formula III for a class of inhibitors of the protease of the formula PI. Among the compounds provided herein, compounds those inhibit HCV NS3/NS4a serine protease activity are preferred.
(FR)La présente invention divulgue un procédé efficace et économique pour la préparation de 6,6-diméthyl-3-azabicyclo-[3.1.0]-hexane racémique de formule I et de ses sels. L'invention concerne des composés de formules I et II. Le composé de formule I est une matière première clef pour la préparation d'un intermédiaire clef de l'acide et de l'ester de (1R, 2S, 5S)-méthyle 6,6-diméthyl-3-azabicyclo[3.1.0]hexane-2-carboxylique et des sels de formule III pour une classe d'inhibiteurs de la protéase de formule PI. Parmi les composés fournis dans la présente, les composés qui inhibent l'activité de la VHC NS3/NS4a sérine protéase sont préférés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)
Licensing availability request The applicant has requested the International Bureau to indicate the availability for licensing purposes of the invention(s) claimed in this international application