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1. (WO2012049658) COMPOUND INHIBITING TP53INP1 ACTIVITY FOR THE TREATMENT OF PROSTATE CANCER, AND ITS USE IN SCREENING AND DIAGNOSTIC METHODS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/049658    International Application No.:    PCT/IB2011/054555
Publication Date: 19.04.2012 International Filing Date: 14.10.2011
IPC:
C12N 15/113 (2010.01), A61K 31/7088 (2006.01), A61P 35/00 (2006.01)
Applicants: ASSISTANCE PUBLIQUE - HOPITAUX DE MARSEILLE [FR/FR]; 80 rue Brochier F-13354 Marseille Cedex (FR) (For All Designated States Except US).
ROCCHI, Palma [FR/FR]; (FR) (For US Only).
GIUSIANO, Sophie [FR/FR]; (FR) (For US Only).
DUSETTI, Nelson [IT/FR]; (FR) (For US Only).
GARCIA, Stéphane [FR/FR]; (FR) (For US Only).
IOVANNA, Juan [IT/FR]; (FR) (For US Only).
BAYLOT, Virginie [FR/FR]; (FR) (For US Only)
Inventors: ROCCHI, Palma; (FR).
GIUSIANO, Sophie; (FR).
DUSETTI, Nelson; (FR).
GARCIA, Stéphane; (FR).
IOVANNA, Juan; (FR).
BAYLOT, Virginie; (FR)
Agent: NOVAGRAAAF TECHNOLOGIES; 122 rue Edouard Vaillant F-92593 Levallois-Perret Cedex (FR)
Priority Data:
10187564.9 14.10.2010 EP
Title (EN) COMPOUND INHIBITING TP53INP1 ACTIVITY FOR THE TREATMENT OF PROSTATE CANCER, AND ITS USE IN SCREENING AND DIAGNOSTIC METHODS
(FR) UTILISATION D'UN COMPOSÉ INHIBITEUR DE L'ACTIVITÉ TP53INP1 DANS LE TRAITEMENT DU CANCER DE LA PROSTATE, ET SON UTILISATION DANS DES MÉTHODES DE DÉPISTAGE ET DE DIAGNOSTIC
Abstract: front page image
(EN)The present invention refers to a compound inhibiting TP53INP1 activity for use in treatment of prostate cancer, a method for in vitro diagnosing a prostate cancer comprising the step of determining the level of expression of β transcript of TP53INP1 gene in a patient-derived biological sample comprising a prostate cell, and to a method of screening for compounds modulating the TP53INP1 activity.
(FR)Cette invention concerne l'utilisation d'un composé inhibiteur de l'activité TP53INP1 dans le traitement du cancer de la prostate. L'invention concerne également une méthode de diagnostic in vitro du cancer de la prostate, consistant à déterminer le taux d'expression du transcrit β du gène TP53INP1 dans un échantillon biologique prélevé chez le patient et comprenant une cellule de la prostate. L'invention concerne en outre une méthode de dépistage de composés modulant l'activité TP53INP1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)