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1. (WO2012049555) SPIROCYCLIC COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/049555 International Application No.: PCT/IB2011/002392
Publication Date: 19.04.2012 International Filing Date: 12.10.2011
IPC:
C07D 491/10 (2006.01) ,C07D 491/20 (2006.01) ,C07D 491/22 (2006.01) ,A61K 31/407 (2006.01) ,A61P 25/00 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
10
Spiro-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
12
in which the condensed system contains three hetero rings
20
Spiro-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
22
in which the condensed system contains four or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
407
condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
LUPIN LIMITED [IN/IN]; 159 CST Road Kalina, Santacruz (East) State of Maharashtra 400 098 Mumbai, IN (AllExceptUS)
PADIYA, Kamlesh, Jyotindra [IN/IN]; IN (UsOnly)
NAIR, Prathap, S. [IN/IN]; IN (UsOnly)
PAL, Ravindra, Ramsurat [IN/IN]; IN (UsOnly)
CHAURE, Ganesh, Shankar [IN/IN]; IN (UsOnly)
GUDADE, Ganesh, Bhausaheb [IN/IN]; IN (UsOnly)
PARKALE, Santosh, Sadashiv [IN/IN]; IN (UsOnly)
MANOJKUMAR, Vishwanath, Lohar [IN/IN]; IN (UsOnly)
SWAPNIL, Ramesh, Bajare [IN/IN]; IN (UsOnly)
SMITA, Aditya, Bhoskar [IN/IN]; IN (UsOnly)
SACHIN, Dilip, Survase [IN/IN]; IN (UsOnly)
PALLE, Venkata, P. [IN/IN]; IN (UsOnly)
KAMBOJ, Rajender, Kumar [IN/IN]; IN (UsOnly)
Inventors:
PADIYA, Kamlesh, Jyotindra; IN
NAIR, Prathap, S.; IN
PAL, Ravindra, Ramsurat; IN
CHAURE, Ganesh, Shankar; IN
GUDADE, Ganesh, Bhausaheb; IN
PARKALE, Santosh, Sadashiv; IN
MANOJKUMAR, Vishwanath, Lohar; IN
SWAPNIL, Ramesh, Bajare; IN
SMITA, Aditya, Bhoskar; IN
SACHIN, Dilip, Survase; IN
PALLE, Venkata, P.; IN
KAMBOJ, Rajender, Kumar; IN
Agent:
MAJUMDAR, Subhatosh; S. Majumdar & Co. 5, Harish Mukherjee Road Calcutta 700 025, IN
Priority Data:
1140/KOL/201013.10.2010IN
1141/KOL/201013.10.2010IN
Title (EN) SPIROCYCLIC COMPOUNDS AS VOLTAGE-GATED SODIUM CHANNEL MODULATORS
(FR) COMPOSÉS SPIROCYCLIQUES EN TANT QUE MODULATEURS DE CANAUX SODIQUES DÉPENDANTS DU VOLTAGE
Abstract:
(EN) The present invention relates to compounds of Formula (I) along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions modulated by VGSCs. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions by modulators of VGSC of Formula (I).
(FR) La présente invention concerne des composés de Formule (I) ainsi que des procédés pour leur préparation, qui sont utiles pour le traitement, la prévention et/ou la gestion des maladies, troubles, syndromes ou états modulés par les canaux sodiques dépendants du voltage (VGSC). L'invention concerne également des procédés de traitement, de prévention, de gestion et/ou de diminution des maladies, troubles, syndromes ou états par des modulateurs des VGSC de Formule (I).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)