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1. (WO2012049439) TREATMENT OF CANCER/INHIBITION OF METASTASIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/049439    International Application No.:    PCT/GB2010/001906
Publication Date: 19.04.2012 International Filing Date: 13.10.2010
IPC:
A61K 31/00 (2006.01), A61K 31/428 (2006.01), A61K 31/495 (2006.01), A61P 35/04 (2006.01)
Applicants: DJAMGOZ, Mustafa, Bilgin, Ali [GB/GB]; (GB)
Inventors: DJAMGOZ, Mustafa, Bilgin, Ali; (GB)
Agent: BERESFORD, Keith, Denis, Lewis; BERESFORD & CO 16 High Holborn London WC1V 6BX (GB)
Priority Data:
Title (EN) TREATMENT OF CANCER/INHIBITION OF METASTASIS
(FR) TRAITEMENT DU CANCER/INHIBITION DE MÉTASTASES
Abstract: front page image
(EN)Substances and methods are disclosed for reducing or preventing metastatic behaviour in VGSC expressing cancer by the effect of at least reducing the persistent part of the voltage gated sodium channel current without eliminating the transient part. Inhibition of metastatic cell behaviours such as detachability, lateral motility, transverse migration and invasiveness is demonstrated using the known drugs ranolazine and riluzole.
(FR)L'invention concerne des substances et des méthodes de réduction ou de prévention d'un comportement métastatique dans une cellule cancéreuse exprimant les canaux sodiques VGSC, au moyen d'au moins une réduction partielle de la partie persistante du courant des canaux sodiques sensibles à la tension sans éliminer la partie transitoire. L'inhibition des comportements cellulaires métastatiques tels que la capacité de détachement, la motilité latérale, la migration transverse et l'invasivité est démontrée à l'aide des médicaments connus que sont la ranolazine et le riluzole.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)