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1. (WO2012049328) GENERATION OF MULTIFUNCTIONAL AND MULTIVALENT POLYPEPTIDE COMPLEXES WITH COLLAGEN XVIII TRIMERIZATION DOMAIN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/049328    International Application No.:    PCT/EP2011/068126
Publication Date: 19.04.2012 International Filing Date: 17.10.2011
IPC:
C07K 14/78 (2006.01), C12N 15/62 (2006.01), C07K 19/00 (2006.01)
Applicants: LEADARTIS, S.L. [ES/ES]; C/ Ferraz, 17 - 1º dcha. E-28008 Madrid (ES) (For All Designated States Except US).
ÁLVAREZ VALLINA, Luis [ES/ES]; (ES) (For US Only).
CUESTA MARTÍNEZ, Ángel [ES/ES]; (ES) (For US Only).
SAINZ PASTOR, Noelia [ES/ES]; (ES) (For US Only).
SANZ ALCOBER, Laura [ES/ES]; (ES) (For US Only)
Inventors: ÁLVAREZ VALLINA, Luis; (ES).
CUESTA MARTÍNEZ, Ángel; (ES).
SAINZ PASTOR, Noelia; (ES).
SANZ ALCOBER, Laura; (ES)
Agent: ALCONADA RODRÍGUEZ, Agustín; ABG Patentes, S.L. Avenida de Burgos, 16D Edificio Euromor E-28036 Madrid (ES)
Priority Data:
10382270.6 15.10.2010 EP
10382271.4 18.10.2010 EP
Title (EN) GENERATION OF MULTIFUNCTIONAL AND MULTIVALENT POLYPEPTIDE COMPLEXES WITH COLLAGEN XVIII TRIMERIZATION DOMAIN
(FR) GÉNÉRATION DE COMPLEXES POLYPEPTIDIQUES MULTIFONCTIONNELS ET MULTIVALENTS À DOMAINE DE TRIMÉRISATION DU COLLAGÈNE XVIII
Abstract: front page image
(EN)The invention relates to the design of trimeric polypeptide complexes using polypeptide structural elements derived from the collagen XVIII protein, and their use in diagnostic and therapeutic systems in vivo and in vitro. The invention also relates to nucleic acids and vectors useful for producing said trimeric complexes.
(FR)L'invention concerne la conception de complexes polypeptidiques trimériques à l'aide d'éléments structuraux polypeptidiques issus de la protéine de collagène XVIII, et leur utilisation dans des systèmes de diagnostic et thérapeutiques in vivo et in vitro. L'invention concerne également des acides nucléiques et des vecteurs utiles pour la production desdits complexes trimériques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)