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1. (WO2012048667) EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT LACKING EXON
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/048667    International Application No.:    PCT/CN2011/081162
Publication Date: 19.04.2012 International Filing Date: 24.10.2011
IPC:
C07K 14/71 (2006.01), C12N 15/12 (2006.01), C12N 15/63 (2006.01), A61K 38/17 (2006.01), A61P 35/04 (2006.01)
Applicants: SHANGHAI CANCER INSTITUTE [CN/CN]; 25/Ln 2200 Xie-tu Road Xuhui District Shanghai 200032 (CN) (For All Designated States Except US).
LI, Zonghai [CN/CN]; (CN) (For US Only).
ZHOU, Min [CN/CN]; (CN) (For US Only).
WANG, Hai [CN/CN]; (CN) (For US Only).
SHI, Bizhi [CN/CN]; (CN) (For US Only).
YANG, Shengli [CN/CN]; (CN) (For US Only).
WANG, Hongyang [CN/CN]; (CN) (For US Only).
GU, Jianren [CN/CN]; (CN) (For US Only)
Inventors: LI, Zonghai; (CN).
ZHOU, Min; (CN).
WANG, Hai; (CN).
SHI, Bizhi; (CN).
YANG, Shengli; (CN).
WANG, Hongyang; (CN).
GU, Jianren; (CN)
Agent: XU & PARTNERS, LLC.; Room No.106, Building No.1, Universal High-Tech Plaza 958 Zhen Bei Road, Putuo District Shanghai 200333 (CN)
Priority Data:
201010510056.3 15.10.2010 CN
Title (EN) EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT LACKING EXON
(FR) VARIANT DU RÉCEPTEUR DE FACTEUR DE CROISSANCE ÉPIDERMIQUE À EXON MANQUANT
(ZH) 表皮生长因子受体的外显子缺失变异体
Abstract: front page image
(EN)The present invention provides an epidermal growth factor receptor variant - de4 EGFR protein. The variant lacks the fourth exon of the epidermal growth factor receptor, and promotes tumor cell invasion/metastasis. The present invention also provides an encoding gene for the variant and a method of producing the variant by means of recombination technology.
(FR)La présente invention concerne un variant de récepteur de facteur de croissance épidermique - la protéine de4 EGFR. Dans le variant, le quatrième exon du récepteur de facteur de croissance épidermique est manquant, favorisant l'invasion/les métastases de cellules tumorales. La présente invention concerne également un gène codant pour le variant et un procédé pour la production du variant par la technologie de recombinaison.
(ZH)本发明提供了一种新的表皮生长因子受体的变异体-de4EGFR蛋白,所述变异体缺失了表皮生长因子受体的第四外显子,具有促进肿瘤细胞侵迁移的功能。本发明还提供了上述变异体的编码基因和经重组技术生产所述变异体的方法。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)