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1. (WO2012048236) MICRORNAS (MIRNA) AS BIOMAKERS FOR THE IDENTIFICATION OF FAMILIAL AND NON-FAMILIAL COLORECTAL CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/048236    International Application No.:    PCT/US2011/055391
Publication Date: 12.04.2012 International Filing Date: 07.10.2011
IPC:
C12Q 1/68 (2006.01)
Applicants: BAYLOR RESEARCH INSTITUTE [US/US]; 3310 Live Oak Street Suite 501 Dallas, TX 75204 (US) (For All Designated States Except US).
GOEL, Ajay [US/US]; (US) (For US Only).
BOLAND, Richard, C. [US/US]; (US) (For US Only).
BALAGUER, Francesc [ES/ES]; (ES) (For US Only).
GIRONELLA I COS, Meritxell [ES/ES]; (ES) (For US Only).
CASTELLS I GARANGOU, Antoni [ES/ES]; (ES) (For US Only).
MOREIRA RUIZ, Leticia [MX/ES]; (ES) (For US Only).
LOZANO SALVATELLA, Juan, Jose [ES/ES]; (ES) (For US Only).
HOSPITAL CLINIC DE BARCELONA [ES/ES]; Villarroel 170 E-08036 Barcelona (ES) (For All Designated States Except US).
CENTRO DE INVESTIGACION EN RED DE ENFERMEDADES HEPATICAS Y DIGESTIVAS [ES/ES]; (CIBEREHD) Villarroel 170 E-08036 Barcelona (ES) (For All Designated States Except US)
Inventors: GOEL, Ajay; (US).
BOLAND, Richard, C.; (US).
BALAGUER, Francesc; (ES).
GIRONELLA I COS, Meritxell; (ES).
CASTELLS I GARANGOU, Antoni; (ES).
MOREIRA RUIZ, Leticia; (ES).
LOZANO SALVATELLA, Juan, Jose; (ES)
Agent: FLORES, Edwin, S.; Chalker Flores, LLP 14951 North Dallas Parkway Suite 400 Dallas, TX 75254 (US)
Priority Data:
61/391,585 08.10.2010 US
13/269,059 07.10.2011 US
Title (EN) MICRORNAS (MIRNA) AS BIOMAKERS FOR THE IDENTIFICATION OF FAMILIAL AND NON-FAMILIAL COLORECTAL CANCER
(FR) MICROARN (MIARN) EN TANT QUE BIOMARQUEURS POUR L'IDENTIFICATION DU CANCER COLORECTAL FAMILIAL ET NON-FAMILIAL
Abstract: front page image
(EN)A technique for the analysis of global miRNA signatures including a larger panel of miRNAs in various roups of well-characterized colorectal cancers (CRCs) is described in the instant invention. The results presented herein provide a large list of miRNAs that are dysregulated in CRC compared to the normal colonic tissue, and, more importantly, the present invention shows for the first time that Lynch syndrome and sporadic MSI tumors exhibit a different miRNA signature that distinguishes them.
(FR)La présente invention concerne une technique pour l'analyse de signatures de miARN globales comprenant un large panel de miARN dans différents groupes de cancers colorectaux caractérisés (CRC). Les résultats présentement décrits fournissent une grande liste de miARN qui sont dérégulés dans le CRC par rapport au tissu du côlon normal, et, plus important, la présente invention montre pour la première fois que le syndrome de Lynch et des tumeurs MSI sporadiques présentent une signature de miARN différente qui les distingue.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)