WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012047852) COMPOSITIONS AND METHODS FOR MODULATING IMMUNODEFICIENCY VIRUS TRANSCRIPTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/047852    International Application No.:    PCT/US2011/054715
Publication Date: 12.04.2012 International Filing Date: 04.10.2011
IPC:
A61K 31/135 (2006.01)
Applicants: THE J. DAVID GLADSTONE INSTITUTES [US/US]; 1650 Owens Street San Francisco, California 94158 (US) (For All Designated States Except US).
OTT, Melanie [DE/US]; (US) (For US Only).
SAKANE, Naoki [JP/JP]; (JP) (For US Only)
Inventors: OTT, Melanie; (US).
SAKANE, Naoki; (JP)
Agent: BORDEN, Paula; Bozicevic Field & Francis Llp 1900 University Avenue, Suite 200 East Palo Alto, California 94303 (US)
Priority Data:
61/390,968 07.10.2010 US
61/431,241 10.01.2011 US
Title (EN) COMPOSITIONS AND METHODS FOR MODULATING IMMUNODEFICIENCY VIRUS TRANSCRIPTION
(FR) COMPOSITIONS ET PROCÉDÉS DE MODULATION DE LA TRANSCRIPTION DE VIRUS D'IMMUNODÉFICIENCE
Abstract: front page image
(EN)The present disclosure provides methods of modulating immunodeficiency virus transcription, involving modulating enzymatic activity and/or levels of a lysine-specific demethylase-1 (LSD1) polypeptide and/or LSD1-mediated demethylation of methylated Tat. The present disclosure also provides method of identifying agents that modulate LSD1-mediated demethylation of a human immunodeficiency virus (HIV) Tat polypeptide.
(FR)La présente invention concerne des procédés de modulation, de la transcription d'un virus d'immunodéficience, qui entraînent la modulation d'une activité enzymatique et/ou des niveaux enzymatiques d'un polypeptide de déméthylase-1 spécifique de la lysine (LSD1) et/ou d'une déméthylation à médiation par LSD1 de Tat méthylé. La présente invention concerne également un procédé d'identification d'agents qui modulent une déméthylation à médiation par LSD1 d'un polypeptide Tat du virus d'immunodéficience humaine (VIH).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)