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1. WO2012047674 - METHODS AND COMPOSITIONS FOR DISEASE TREATMENT USING INHALATION

Publication Number WO/2012/047674
Publication Date 12.04.2012
International Application No. PCT/US2011/053513
International Filing Date 27.09.2011
IPC
A61P 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
CPC
A61K 31/137
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines
135having aromatic rings ; , e.g. ketamine, nortriptyline
137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine ; or methadone
A61K 31/203
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
20having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
203Retinoic acids ; Salts thereof
A61K 31/56
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
A61K 31/573
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573substituted in position 21, e.g. cortisone, dexamethasone, prednisone ; or aldosterone
A61K 31/58
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
58containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 31/593
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
59Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
5939,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
Applicants
  • MICRODOSE THERAPEUTX, INC. [US]/[US] (AllExceptUS)
  • BYRON, David, A. [US]/[US] (UsOnly)
  • WATTS, Alan, B. [US]/[US] (UsOnly)
  • COOK, Robert, O. [GB]/[US] (UsOnly)
  • AYDIN, Murat [US]/[US] (UsOnly)
Inventors
  • BYRON, David, A.
  • WATTS, Alan, B.
  • COOK, Robert, O.
  • AYDIN, Murat
Agents
  • SOLOWAY, Norman, P.
Priority Data
61/386,73327.09.2010US
61/386,76727.09.2010US
61/386,77127.09.2010US
61/386,77627.09.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR DISEASE TREATMENT USING INHALATION
(FR) PROCÉDÉS ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIE EN UTILISANT L'INHALATION
Abstract
(EN)
Methods and compositions for the treatment of pulmonary disease using inhalation are provided. In particular, the present disclosure provides novel methods and compositions for treating pulmonary diseases such as asthma, bronchitis, COPD, emphysema, lung cancer, pneumonia and pulmonary edema. In addition, the present disclosure provides novel methods and compositions for treating complications associated with pulmonary disease such as corticosteroid resistance and pulmonary tissue destruction. The compositions of the present disclosure comprise corticosteroid resistance agents including but not limited to vitamin D, calcitriol and equivalents thereof. The compositions of the present disclosure also comprise alveolar development and maintenance agents including but not limited to vitamin A, ATRA and equivalents thereof. The present invention provides effective administration of therapeutic agents to specific airways of the lungs by utilizing controlled site delivery.
(FR)
La présente invention concerne des procédés et des compositions pour le traitement d'une maladie pulmonaire en utilisant l'inhalation. En particulier, la présente description concerne de nouveaux procédés et compositions pour traiter des maladies pulmonaires telles que l'asthme, la bronchite, la BPCO, l'emphysème, le cancer du poumon, la pneumonie et l'œdème pulmonaire. De plus, la présente description concerne de nouveaux procédés et compositions pour traiter des complications associées à une maladie pulmonaire telle que la résistance aux corticostéroïdes et la destruction de tissu pulmonaire. Les compositions de la présente description comprennent des agents de résistance aux corticostéroïdes comprenant mais non limitées à la vitamine D, le calcitriol et des équivalents de ceux-ci. Les compositions de la présente description comprennent en outre des agents de développement et de maintenance alvéolaire comprenant, mais non limités à, la vitamine A, ATRA et des équivalents de ceux-ci. La présente invention concerne l'administration efficace d'agents thérapeutiques à des voies respiratoires spécifiques des poumons en utilisant l'administration à un site contrôlé.
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