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Pub. No.:    WO/2012/047645    International Application No.:    PCT/US2011/053440
Publication Date: 12.04.2012 International Filing Date: 27.09.2011
A61K 31/498 (2006.01), A61K 31/4168 (2006.01), A61K 31/4164 (2006.01), A61P 17/00 (2006.01), A61P 29/00 (2006.01)
Applicants: GALDERMA S.A. [CH/CH]; World Trade Center Avenue Gratta-Paille 1 CH-1000 Lausanne 30 Grey (CH) (For All Designated States Except US).
GRAEBER, Michael [DE/US]; (US) (For US Only).
LEONI, Matthew, James [US/US]; (US) (For US Only).
WAGNER, Nathalie [FR/FR]; (FR) (For US Only)
Inventors: GRAEBER, Michael; (US).
LEONI, Matthew, James; (US).
WAGNER, Nathalie; (FR)
Agent: BARON, Ronald, J.; Hoffmann & Baron, LLP 6900 Jericho Turnpike Suite 200 Syosset, NY 11791 (US)
Priority Data:
13/232,134 14.09.2011 US
61/387,260 28.09.2010 US
Abstract: front page image
(EN)The invention relates to a method of treating erythema and/or telangiectasia associated with rosacea in a patient in need thereof by topically administering an effective amount of a combination of brimonidine or a pharmaceutically acceptable salt thereof and oxymetazoline or a pharmaceutically acceptable salt thereof to the site of erythema and/or telangiectasia on the skin of the patient. The invention further relates to topical compositions including the combination of compounds and a pharmaceutically acceptable carrier.
(FR)L'invention concerne un procédé de traitement de l'érythème et/ou de la télangiectasie associés à l'acné rosacée chez un patient nécessitant de celui-ci par administration par voie topique d'une quantité efficace d'une combinaison de brimonidine ou d'un sel pharmaceutiquement acceptable de celle-ci et d'oxymétazoline ou d'un sel pharmaceutiquement acceptable de celle-ci au site de l'érythème et/ou de la télangiectasie sur la peau du patient. L'invention concerne en plus les compositions topiques incluant la combinaison des composés et d'un support pharmaceutiquement acceptable.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)