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Machine translation
1. (WO2012047538) BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/047538    International Application No.:    PCT/US2011/052857
Publication Date: 12.04.2012 International Filing Date: 23.09.2011
IPC:
A01N 43/52 (2006.01), A61K 31/4164 (2006.01)
Applicants: GLAXOSMITHKLINE LLC [US/US]; One Franklin Plaza 200 N. 16th Street Philadelphia, Pennsylvania 19102 (US) (For All Designated States Except US).
QU, Junya [CN/US]; (US) (For US Only).
RIVERO, Ralph [US/US]; (US) (For US Only).
SANCHEZ, Robert [US/US]; (US) (For US Only).
TEDESCO, Rosanna [IT/US]; (US) (For US Only)
Inventors: QU, Junya; (US).
RIVERO, Ralph; (US).
SANCHEZ, Robert; (US).
TEDESCO, Rosanna; (US)
Agent: YOUNG, J. Scott; c/o GlaxoSmithKline Global Patents Department Five Moore Drive P. O. Box 13398 Research Triangle Park, North Carolina 27709 (US)
Priority Data:
61/390,314 06.10.2010 US
61/528,397 29.08.2011 US
Title (EN) BENZIMIDAZOLE DERIVATIVES AS PI3 KINASE INHIBITORS
(FR) DÉRIVÉS DE BENZIMIDAZOLE UTILISÉS COMME INHIBITEURS DE PI3 KINASE
Abstract: front page image
(EN)This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3' OH kinase family (hereinafter PI3 kinases), suitably, PI3Kα, PI3Kδ, PI3Kβ, and/or PI3Kγ. Suitably, the present invention relates to the use of benzimidazoles in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries. More suitably, the present invention relates to PI3Kβ selective benzimidazoles compounds for treating cancer.
(FR)Cette invention concerne l'utilisation de dérivés de benzimidazole pour la modulation, notamment l'inhibition de l'activité ou de la fonction de la famille des phosphoinositide-3-OH kinases (désignées ci-après PI3 kinases), en particulier la PI3Kα, la PI3Kδ, la PI3Kβ, et/ou la PI3Kγ. La présente invention concerne plus particulièrement l'utilisation de benzimidazoles dans le traitement d'un ou plusieurs états maladifs choisis parmi les troubles auto-immuns, les maladies inflammatoires, les maladies cardio-vasculaires, les maladies neurodégénératives, l'allergie, l'asthme, la pancréatite, la défaillance de plusieurs organes, les néphropathies, l'agrégation plaquettaire, le cancer, la motilité du sperme, le rejet d'une transplantation, le rejet de greffe et les lésions pulmonaires. Mieux, la présente invention concerne des composés de benzimidazole sélectifs envers la PI3Kβ pour traiter le cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)