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Pub. No.:    WO/2012/047427    International Application No.:    PCT/US2011/050050
Publication Date: 12.04.2012 International Filing Date: 31.08.2011
C07K 16/12 (2006.01), C12P 21/08 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, Twelfth Floor Oakland, CA 94607 (US) (For All Designated States Except US).
MARKS, James, D. [US/US]; (US) (For US Only).
FAN, Yongfeng [CN/US]; (US) (For US Only).
LOU, Jianlong [CN/US]; (US) (For US Only).
RODRIGUEZ, Maria Consuelo Garcia [MX/US]; (US) (For US Only).
YAN, Shude [CN/US]; (US) (For US Only).
GEREN, Isin, Nergiz [TR/TR]; (TR) (For US Only).
ZHAI, Wenwu [US/US]; (US) (For US Only).
CHAKRABORTI, Subhendu [IN/US]; (US) (For US Only)
Inventors: MARKS, James, D.; (US).
FAN, Yongfeng; (US).
LOU, Jianlong; (US).
RODRIGUEZ, Maria Consuelo Garcia; (US).
YAN, Shude; (US).
GEREN, Isin, Nergiz; (TR).
ZHAI, Wenwu; (US).
Agent: BORDEN, Paula A.; Bozicevic Field & Francis LLP 1900 University Avenue, Suite 200 East Palo Alto, CA 94303 (US)
Priority Data:
61/378,862 31.08.2010 US
61/430,084 05.01.2011 US
Abstract: front page image
(EN)The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
(FR)La présente invention concerne des anticorps se liant spécifiquement aux neurotoxines botuliques (par exemple BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) ainsi que les épitopes liés par ces anticorps. Les anticorps et leurs dérivés qui se lient spécifiquement aux épitopes neutralisants selon la présente invention peuvent être employés pour neutraliser la neurotoxine botulique et sont également utiles dans le traitement du botulisme.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)