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1. (WO2012047109) MIRNA AND MIRNA INHIBITORS THAT MODULATE ADENOVIRUS REPLICATION AND/OR ADENOVIRUS INDUCED CELL DEATH
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/047109    International Application No.:    PCT/NL2011/050688
Publication Date: 12.04.2012 International Filing Date: 07.10.2011
IPC:
C12Q 1/68 (2006.01), C12Q 1/70 (2006.01)
Applicants: ORCA THERAPEUTICS B.V. [NL/NL]; Professor Bronkhorstlaan 10-92 NL-3723 MB Bilthoven (NL) (For All Designated States Except US).
VAN BEUSECHEM, Victor Willem [NL/NL]; (NL) (For US Only).
VAN GINKEL, Jan Willem Hendrik [NL/NL]; (NL) (For US Only)
Inventors: VAN BEUSECHEM, Victor Willem; (NL).
VAN GINKEL, Jan Willem Hendrik; (NL)
Agent: JANSEN, C.m.; VEREENIGDE Johan de Wittlaan 7 NL-2517 JR Den Haag (NL)
Priority Data:
10187049.1 08.10.2010 EP
61/391,135 08.10.2010 US
Title (EN) MIRNA AND MIRNA INHIBITORS THAT MODULATE ADENOVIRUS REPLICATION AND/OR ADENOVIRUS INDUCED CELL DEATH
(FR) MIARN ET INHIBITEURS DE MIARN MODULANT LA RÉPLICATION D'ADÉNOVIRUS ET/OU LA MORT CELLULAIRE INDUITE PAR ADÉNOVIRUS
Abstract: front page image
(EN)The invention relates to means and methods for identifying a mi RNA, a mi RNA mimic or a mi RNA inhibitor that modulates adenovirus replication in, and/or adenovirus induced cell death of a cell. Identified mi RNAs, mi RNA mimics or mi RNA inhibitors are used as anti-cancer agents in the context of adenovirus gene therapy.
(FR)L'invention concerne des moyens et des méthodes d'identification d'un miARN, d'un mimic de miARN ou d'un inhibiteur de miARN qui module la réplication d'adénovirus dans une cellule et/ou la mort cellulaire induite par adénovirus d'une cellule. Des miARN, mimics de miARN ou inhibiteurs de miARN identifiés servent d'agents anticancéreux dans le contexte de la thérapie génique par adénovirus.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)