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1. (WO2012046945) PHARMACEUTICAL AND FOOD COMPOSITION FOR PREVENTING OR TREATING DIABETES OR OBESITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/046945    International Application No.:    PCT/KR2011/004836
Publication Date: 12.04.2012 International Filing Date: 01.07.2011
IPC:
A61K 31/357 (2006.01), A61K 31/343 (2006.01), C07D 307/88 (2006.01), A61P 3/10 (2006.01), A61P 3/04 (2006.01)
Applicants: KOREA OCEAN RESEARCH AND DEVELOPMENT INSITUTE [KR/KR]; 7-50, Sondo-dong Yeonsu-gu Incheon 406-804 (KR) (For All Designated States Except US).
YIM, Jong Han [KR/KR]; (KR) (For US Only).
KIM, Il Chan [KR/KR]; (KR) (For US Only).
KIM, Doc Kyu [KR/KR]; (KR) (For US Only).
HAN, Se Jong [KR/KR]; (KR) (For US Only).
LEE, Hyoung Seok [KR/KR]; (KR) (For US Only).
Hari Datta, Bhattarai [NP/KR]; (KR) (For US Only).
KIM, Jung Eun [KR/KR]; (KR) (For US Only).
KIM, Tai Kyoung [KR/KR]; (KR) (For US Only).
OH, Hyun Cheol [KR/KR]; (KR) (For US Only).
JO, Dong-Gyu [KR/KR]; (KR) (For US Only).
LEE, Cheolsoon [KR/KR]; (KR) (For US Only).
KIM, Keun-Sik [KR/KR]; (KR) (For US Only).
LEE, Pyung Cheon [KR/KR]; (KR) (For US Only).
PARK, Mi Ra [KR/KR]; (KR) (For US Only).
PARK, Yu-Kyung [KR/KR]; (KR) (For US Only).
KIM, Sung Jin [KR/KR]; (KR) (For US Only).
KANG, Pil-Sung [KR/KR]; (KR) (For US Only).
PARK, Heeyong [KR/KR]; (KR) (For US Only).
PARK, Ha Ju [KR/KR]; (KR) (For US Only)
Inventors: YIM, Jong Han; (KR).
KIM, Il Chan; (KR).
KIM, Doc Kyu; (KR).
HAN, Se Jong; (KR).
LEE, Hyoung Seok; (KR).
Hari Datta, Bhattarai; (KR).
KIM, Jung Eun; (KR).
KIM, Tai Kyoung; (KR).
OH, Hyun Cheol; (KR).
JO, Dong-Gyu; (KR).
LEE, Cheolsoon; (KR).
KIM, Keun-Sik; (KR).
LEE, Pyung Cheon; (KR).
PARK, Mi Ra; (KR).
PARK, Yu-Kyung; (KR).
KIM, Sung Jin; (KR).
KANG, Pil-Sung; (KR).
PARK, Heeyong; (KR).
PARK, Ha Ju; (KR)
Agent: LEE, Cheo Young; 11th, Yeosam Bldg., 648-23 Yeoksam-dong, Gangnam-gu Seoul 135-080 (KR)
Priority Data:
10-2010-0097677 07.10.2010 KR
10-2010-0097678 07.10.2010 KR
10-2011-0039155 26.04.2011 KR
Title (EN) PHARMACEUTICAL AND FOOD COMPOSITION FOR PREVENTING OR TREATING DIABETES OR OBESITY
(FR) COMPOSITION PHARMACEUTIQUE ET ALIMENTAIRE POUR LA PRÉVENTION OU LE TRAITEMENT DU DIABÈTE OU DE L'OBÉSITÉ
(KO) 당뇨병 또는 비만의 예방 또는 치료용 약학 및 식품 조성물
Abstract: front page image
(EN)The present invention relates to a pharmaceutical and food composition for preventing or treating diabetes or obesity, and more particularly, to a pharmaceutical composition and functional food for preventing or treating diabetes or obesity and which contain, as active ingredients, novel compounds synthesized from compounds separated from extracts of Stereocaulon alpinum, which is an Antarctic lichen. The novel compounds of the present invention have an excellent activity of inhibiting protein tyrosine phosphatase-1b (PTP-1b), may selectively influence only PTP-1b from among protein tyrosine phosphatases, and may be used as a substantial PTP-1b inhibitor in treating diabetes, and thus may be effectively used in preventing or treating diabetes and obesity.
(FR)La présente invention concerne une composition pharmaceutique et alimentaire pour la prévention ou le traitement du diabète ou de l'obésité. L'invention porte plus particulièrement sur une composition pharmaceutique et un aliment fonctionnel pour la prévention ou le traitement du diabète ou de l'obésité contenant, en tant que principes actifs, de nouveaux composés synthétisés à partir de composés séparés d'extraits de Stereocaulon alpinum, qui est un lichen antarctique. Les nouveaux composés de la présente invention possèdent une excellente activité d'inhibition de la tyrosine phosphatase-1b (PTP-1b), peuvent influencer sélectivement la PTP-1b uniquement parmi des protéines tyrosine phosphatases, peuvent être utilisés en tant qu'inhibiteurs notables de la PTP-1b dans le traitement du diabète, et peuvent ainsi être utilisés efficacement dans la prévention ou le traitement du diabète ou de l'obésité.
(KO)본 발명은 당뇨병 또는 비만의 예방 또는 치료용 약학 및 식품 조성물에 관한 것으로, 보다 구체적으로는, 남극 지의류인 스테레오카울론 알피넘 (Stereocaulon alpinum) 추출물에서 분리한 화합물로부터 합성한 신규 화합물을 유효성분으로 함유하는 당뇨병 또는 비만의 예방 또는 치료용 약학 조성물과 기능성 식품에 관한 것이다. 본 발명에 따른 신규 화합물은 PTP-1b (protein tyrosine phosphatase-1b) 저해활성이 매우 뛰어나며, 단백질타이로신탈인산화효소족 중 PTP-1b에만 선택적으로 작용하고, 실질적인 PTP-1b 저해제로 당뇨치료에 이용가능한바, 당뇨병 및 비만의 예방 또는 치료에 효과적이다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)