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1. (WO2012046940) COMPOSITION FOR NATURAL KILLER CELL DIFFERENTIATION CONTAINING A TOX AS AN ACTIVE INGREDIENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/046940    International Application No.:    PCT/KR2011/003715
Publication Date: 12.04.2012 International Filing Date: 19.05.2011
IPC:
C12N 5/0783 (2010.01), C12N 5/02 (2006.01), C07K 14/47 (2006.01)
Applicants: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY [KR/KR]; 111 Gwahangno Yuseong-gu Daejeon 305-806 (KR) (For All Designated States Except US).
CHOI, In Pyo [KR/KR]; (KR) (For US Only).
YUN, So Hyun [KR/KR]; (KR) (For US Only).
YOON, Suk-Ran [KR/KR]; (KR) (For US Only)
Inventors: CHOI, In Pyo; (KR).
YUN, So Hyun; (KR).
YOON, Suk-Ran; (KR)
Agent: LEE, Won Hee; 8th Fl. Sung-ji Heights II 642-16 Yoksam-dong Kangnam-ku Seoul 135-080 (KR)
Priority Data:
10-2010-0097206 06.10.2010 KR
Title (EN) COMPOSITION FOR NATURAL KILLER CELL DIFFERENTIATION CONTAINING A TOX AS AN ACTIVE INGREDIENT
(FR) COMPOSITION DE DIFFÉRENCIATION DES CELLULES NK NATURELLES CONTENANT UNE TOX COMME INGRÉDIENT ACTIF
(KO) TOX를 유효성분으로 함유하는 자연살해세포 분화용 조성물
Abstract: front page image
(EN)The present invention relates to a composition for natural killer cell differentiation containing a TOX (thymocyte selection-associated HMG box protein) as an active ingredient and to a differentiation method using the same, and, more specifically, the TOX can be used to advantage in inducing natural killer cell differentiation since TOX regulates the expression of T-bet which induces differentiation from haematopoietic stem cells to natural killer cells and is known to be an important regulator in the process of differentiation of natural killer cells.
(FR)L'invention se rapporte à une composition permettant la différenciation des cellules NK naturelles, laquelle composition contient une TOX (protéine HMG box associée à la sélection des thymocytes) comme ingrédient actif. L'invention concerne également un procédé de différenciation faisant appel à ladite composition selon lequel, en particulier, on met à profit la TOX afin d'induire la différenciation des cellules NK naturelles, la TOX régulant l'expression de T-bet qui induit la différenciation des cellules souches hématopoïétiques en cellules NK, et étant connue pour être un régulateur important dans le processus de différenciation des cellules NK naturelles.
(KO)본 발명은 TOX(thymocyte selection-associated HMG box protein)를 유효성분으로 함유하는 자연살해세포 분화용 조성물 및 이를 이용한 분화 방법에 관한 것으로 보다 상세하게는, TOX는 조혈 줄기세포에서 자연살해세포로의 분화를 유도하고 자연 살해세포의 분화과정 중 중요한 조절자로 알려진 T-bet의 발현을 조절하므로 TOX를 이용하여 자연살해세포 분화 유도에 유용하게 사용될 수 있다.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Korean (KO)
Filing Language: Korean (KO)