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1. (WO2012046081) MALARIA VACCINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/046081    International Application No.:    PCT/GB2011/051936
Publication Date: 12.04.2012 International Filing Date: 07.10.2011
A61K 39/015 (2006.01), C07K 16/20 (2006.01)
Applicants: GENOME RESEARCH LIMITED [GB/GB]; Gibbs Building 215 Euston Road London Greater London NW1 2BE (GB) (For All Designated States Except US).
WRIGHT, Gavin, J. [GB/GB]; (GB) (For US Only).
RAYNER, Julian, C. [GB/GB]; (GB) (For US Only).
CROSNIER, Cecile [FR/GB]; (GB) (For US Only).
BUSTAMANTE, Leyla, Y. [CO/GB]; (GB) (For US Only).
BARTHOLDSON, S. Josefin [SE/GB]; (GB) (For US Only)
Inventors: WRIGHT, Gavin, J.; (GB).
RAYNER, Julian, C.; (GB).
CROSNIER, Cecile; (GB).
BUSTAMANTE, Leyla, Y.; (GB).
Agent: OLSWANG LLP; 90 High Holborn London Greater London WC1V 6XX (GB)
Priority Data:
1016969.6 08.10.2010 GB
Abstract: front page image
(EN)Immunogenic compositions and vaccines against Plasmodialinfection comprising an Rh polypeptide or a fragment or variant thereof are dislcosed. Also disclosed are Rh5 polypeptides or fragments or variants thereof capable of binding CD147 and conferring protection against infection and/or disease caused by multiple Plasmodial strains or Plasmodialspecies, inhibitors of the interaction between Rh5 and CD147 and methods for producing polypeptides in a mammalian expression system.
(FR)La présente invention concerne des compositions immunogènes et des vaccins contre une infection plasmodiale, comprenant un polypeptide Rh, ou un fragment ou une variante de celui-ci. L'invention porte en outre sur des polypeptides Rh5 ou sur des fragments ou des variantes de celui-ci, aptes à se lier à CD147 et à conférer une protection contre une infection et/ou une pathologie provoquée par plusieurs souches de Plasmodium ou espèces de Plasmodium. L'invention a également trait à des inhibiteurs de l'interaction entre Rh5 et CD147, et à des procédés de production de polypeptides dans un système d'expression mammifère.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)