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1. (WO2012045999) PHOSPHORAMIDITE DERIVATIVES OF GEMCITABINE FOR USE IN THE TREATMENT CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/045999    International Application No.:    PCT/GB2011/001446
Publication Date: 12.04.2012 International Filing Date: 05.10.2011
IPC:
C07H 19/10 (2006.01), A61K 31/7068 (2006.01), A61P 35/00 (2006.01)
Applicants: NUCANA BIOMED LIMITED [GB/GB]; Basset House 5 Southwell Park Road Camberley Surrey GU15 3PU (GB) (For All Designated States Except US).
MCGUIGAN, Christopher [GB/GB]; (GB) (For US Only)
Inventors: MCGUIGAN, Christopher; (GB)
Agent: HOWARD, Paul, Nicholas; Carpmaels & Ransford One Southampton Row London WC1B 5HA (GB)
Priority Data:
1016855.7 06.10.2010 GB
Title (EN) PHOSPHORAMIDITE DERIVATIVES OF GEMCITABINE FOR USE IN THE TREATMENT CANCER
(FR) DÉRIVÉS DE TYPE PHOSPHORAMIDITE DE GEMCITABINE POUR APPLICATION AU TRAITEMENT DU CANCER
Abstract: front page image
(EN)Phosphorodiamidate derivatives of e.g. gemcitabine are provided for use in treating cancer. In one embodiment, the two amidate motifs each comprises NR'R" where R' is H and R" is CR5R6CO2R7, where R6 is H, R5 is the side chain, including H and C1, of a naturally occuuring alpha amino acid, and R7 is branched or unbranched, substituted or unsubstiruted, acyclic or cyclic alkyl, including t-butyl-CH2-, benzyl and C3 to C6 cycloalkyl.Formula (I).
(FR)La présente invention concerne des dérivés de type phosphorodiamidate de, par exemple, la gemcitabine, pour application au traitement du cancer. Dans l'un des modes de réalisation, chacun des deux motifs amidate comprend NR'R" où R' représente H et R" représente CR5R6CO2R7, où R6 représente H, R5 représente la chaîne latérale, y compris H et C1, d'un acide alpha-aminé naturel, et R7 représent un groupement alkyle linéaire ou ramifié, substitué ou non substitué, acyclique ou cyclique, y compris t-butyl-CH2-, benzyle et cycloalkyle en C3 à C6. Formule (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)