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Pub. No.:    WO/2012/045994    International Application No.:    PCT/GB2011/001441
Publication Date: 12.04.2012 International Filing Date: 04.10.2011
A61K 9/51 (2006.01)
Applicants: IOTA NANOSOLUTIONS LIMITED [GB/GB]; 100 Victoria Embankment London EC4Y 0DY (GB) (For All Designated States Except US).
RANNARD, Steven, Paul [GB/GB]; (GB) (For US Only).
DUNCALF, David [GB/GB]; (GB) (For US Only).
FOSTER, Alison, Jayne [GB/GB]; (GB) (For US Only).
LONG, James [GB/GB]; (GB) (For US Only).
WANG, Dong [CN/GB]; (GB) (For US Only)
Inventors: RANNARD, Steven, Paul; (GB).
DUNCALF, David; (GB).
FOSTER, Alison, Jayne; (GB).
LONG, James; (GB).
WANG, Dong; (GB)
Agent: CAWLEY, Aimee; Marks & Clerk LLP 1 New York Street Manchester M1 4HD (GB)
Priority Data:
1016765.8 05.10.2010 GB
1016776.5 05.10.2010 GB
Abstract: front page image
(EN)The invention provides a method for preparing an improved composition comprising at least one active agent and at least one solid carrier material, wherein the active agent is dispersed through the carrier material in nano-disperse form, which method comprises the steps of: (a) forming a liquid mixture comprising the active agent, the carrier material, a stabilizing agent, a first solvent for the active agent and the stabilizing agent and, a second solvent for the carrier material, and (b) drying the liquid mixture to remove the first and second solvents to obtain a substantially solvent-free nano-dispersion of the active agent with the stabilising agent in the carrier material, wherein the stabilizing agent is capable of stabilizing the active agent in the liquid mixture during drying and in a resultant liquid nano-dispersion of the improved composition.
(FR)L'invention concerne un procédé de préparation de composition améliorée comprenant au moins un agent actif et au moins une matière support solide, l'agent actif étant dispersé à travers la matière support sous forme de nano-dispersion. Le procédé comprend les étapes consistant à : (a) former un mélange liquide comprenant l'agent actif, la matière support, un agent stabilisant, un premier solvant pour l'agent actif et l'agent stabilisant et un second solvant pour la matière support, et (b) sécher le mélange liquide pour éliminer les premier et second solvants afin d'obtenir une nano-dispersion sensiblement exempte de solvant de l'agent actif avec l'agent stabilisant dans la matière support, l'agent stabilisant étant capable de stabiliser l'agent actif dans le mélange liquide au cours du séchage et dans une nano-dispersion liquide résultante de la composition améliorée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)