WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |

Search International and National Patent Collections
World Intellectual Property Organization
Machine translation
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/045085    International Application No.:    PCT/US2011/054645
Publication Date: 05.04.2012 International Filing Date: 03.10.2011
C07K 16/28 (2006.01), C07K 16/30 (2006.01), A61K 39/395 (2006.01), A61P 35/02 (2006.01)
Applicants: OXFORD BIOTHERAPEUTICS LTD. [GB/GB]; 94a Milton Park Abingdon Oxon OX14 4RY (GB) (For All Designated States Except US).
ROHLFF, Christian [DE/GB]; (GB) (For US Only).
STAMPS, Alasdair [GB/GB]; (GB) (For US Only).
TERRETT, Jonathan, Alexander [GB/US]; (US) (For US Only)
Inventors: ROHLFF, Christian; (GB).
STAMPS, Alasdair; (GB).
TERRETT, Jonathan, Alexander; (US)
Agent: SILVA, Robin, M.; Morgan Lewis & Bockius LLP One Market, Spear Street Tower San Francisco, CA 94105 (US)
Priority Data:
61/388,694 01.10.2010 US
61/482,554 04.05.2011 US
Abstract: front page image
(EN)The invention provides antibodies which bind to the extracellular domain of the Tyrosine- protein kinase transmembrane receptor ROR1. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of cancer, including non-small cell lung carcinoma, B-cell chronic lymphocytic leukemia and colon cancer.
(FR)La présente invention concerne des anticorps se liant au domaine extracellulaire du récepteur transmembranaire de protéine kinase tyrosine ROR1, et concerne également des molécules d'acide nucléique codant les anticorps, des vecteurs d'expression, des cellules hôtes et des méthodes d'expression des anticorps. Les anticorps peuvent être utilisés pour le traitement du cancer, y compris l'épithélioma pulmonaire à grandes cellules, la leucémie lymphocytique chronique à lymphome B et le cancer du côlon.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)