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1. (WO2012044979) MANIPULATION OF STEM CELL FUNCTION BY P53 ISOFORMS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/044979    International Application No.:    PCT/US2011/054304
Publication Date: 05.04.2012 International Filing Date: 30.09.2011
IPC:
C12N 5/0789 (2010.01)
Applicants: THE GOVERMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer 6011 Executive Blvd. Suite 325 Rockville, Maryland 20852 (US) (For All Designated States Except US).
HARRIS, Curtis C. [US/US]; (US) (For US Only).
HORIKAWA, Izumi [JP/US]; (US) (For US Only).
FUJITA, Kaori [JP/US]; (US) (For US Only).
MONDAL, Abdul M. [IN/US]; (US) (For US Only).
PARK, Kye-Yoon [KR/US]; (US) (For US Only).
PINE, Sharon R. [US/US]; (US) (For US Only).
SERRANO, Manuel [ES/US]; (US) (For US Only)
Inventors: HARRIS, Curtis C.; (US).
HORIKAWA, Izumi; (US).
FUJITA, Kaori; (US).
MONDAL, Abdul M.; (US).
PARK, Kye-Yoon; (US).
PINE, Sharon R.; (US).
SERRANO, Manuel; (US)
Agent: LOCKYER, Jean M.; Kilpatrick Townsend & Stockton LLP Two Embarcadero Center, Eighth Floor San Francisco, California 94111-3834 (US)
Priority Data:
61/389,134 01.10.2010 US
Title (EN) MANIPULATION OF STEM CELL FUNCTION BY P53 ISOFORMS
(FR) MANIPULATION DE LA FONCTION DE CELLULES SOUCHES PAR DES ISOFORMES P53
Abstract: front page image
(EN)This invention provides methods and compositions for increasing the efficiency of obtaining pluripotent stem cells, the method comprising expressing a 133p53 in cells that are being re-programmed to obtain pluripotent cells. The invention also provides method of inhibiting the proliferation of cancer stem cells, the method comprising suppressing expression of 133p53 in the cells.
(FR)Cette invention concerne des méthodes et des compositions pouvant augmenter l'efficacité de production de cellules souches pluripotentes. Le procédé consiste à exprimer un 133p53 dans des cellules reprogrammées pour produire des cellules pluripotentes. L'invention concerne également une méthode pouvant inhiber la prolifération de cellules souches du cancer, qui consiste à supprimer l'expression de 133p53 dans les cellules.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)