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Machine translation
1. (WO2012044936) COMBINATION THERAPY WITH 4-(3-(2H-1,2,3-TRIAZOL-2-YL)PHENYLAMINO)-2-((1R,2S)-2-AMINOCYCLOHEXYLAMINO)PYRIMIDINE-5-CARBOXAMIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/044936    International Application No.:    PCT/US2011/054233
Publication Date: 05.04.2012 International Filing Date: 30.09.2011
Chapter 2 Demand Filed:    27.07.2012    
IPC:
A61K 31/505 (2006.01), A61P 35/00 (2006.01)
Applicants: PORTOLA PHARMACEUTICALS, INC. [US/US]; 270 E. Grand Avenue, Suite 22 South San Francisco, California 94080 (US) (For All Designated States Except US).
SINHA, Uma [US/US]; (US) (For US Only).
PANDEY, Anjali [US/US]; (US) (For US Only)
Inventors: SINHA, Uma; (US).
PANDEY, Anjali; (US)
Agent: HOPKINS, Mark H.; Kilpatrick Townsend & Stockton LLP Two Embarcadero Center, Eighth Floor San Francisco, California 94111-3834 (US)
Priority Data:
61/388,568 30.09.2010 US
Title (EN) COMBINATION THERAPY WITH 4-(3-(2H-1,2,3-TRIAZOL-2-YL)PHENYLAMINO)-2-((1R,2S)-2-AMINOCYCLOHEXYLAMINO)PYRIMIDINE-5-CARBOXAMIDE
(FR) POLYTHÉRAPIE AVEC DU 4-(3-(2H-1,2,3-TRIAZOL-2-YL)PHÉNYLAMINO)-2-((1R,2S)-2- AMINOCYCLOHEXYLAMINO)PYRIMIDINE-5-CARBOXAMIDE
Abstract: front page image
(EN)The present invention is directed to pharmaceutical compositions and methods of using combination therapies containing a SYK inhibitor, or a pharmaceutically acceptable salt thereof, and a antineoplastic or antiinflammatory agent for the treatment of inflammatory, autoimmune and cell proliferative diseases, such as allergic reaction, transplant rejection, rheumatoid arthritis (RA), lupus, multiple sclerosis (MS) or psoriasis undesired acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), non-Hodgkin lymphoma (NHL) (including diffuse large B cell lymphoma (DLBCL)), mantle cell lymphoma, acute lymphocytic leukemia (ALL), follicular lymphoma, Burkitt's lymphoma, small Lymphocytic (SLL), Lymphoma, multiple myeloma, asthma, vasculitis, Idiopathic thrombocytopenic purpura (ITP), Heparin Induced Thrombocytopenia (HIT) and hemolytic anemia.
(FR)La présente invention concerne des compositions pharmaceutiques et des méthodes d'utilisation de polythérapies contenant un inhibiteur de la Syk, ou l'un de ses sels pharmaceutiquement acceptables, ainsi qu'un agent antinéoplasique ou anti-inflammatoire pour le traitement de maladies inflammatoires, auto-immunes et de prolifération cellulaire, telles qu'une réaction d'allergie, un rejet de greffe, la polyarthrite rhumatoïde (PR), un lupus, la sclérose en plaques (SEP) ou un psoriasis, une leucémie aiguë myéloïde indésirable (LAM), une leucémie chronique lymphocytaire (LCL), un lymphome non hodgkinien (LNH) (y compris un lymphome à gros lymphocytes B diffus), un lymphome à cellules du manteau, une leucémie aiguë lymphocytaire (LAL), un lymphome folliculaire, le lymphome de Burkitt, un petit lymphome lymphocytaire (PLL), un myélome multiple, un asthme, une vasculite, un purpura thrombocytopénique idiopathique (PTI), une thrombocytopénie induite par l'héparine (TIH) et une anémie hémolytique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)