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1. (WO2012044689) (20R,25S)-2-METHYLENE-19,26-DINOR-1α, 25-DIHYDROXYVITAMIN D3 IN CRYSTALLINE FORM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/044689    International Application No.:    PCT/US2011/053693
Publication Date: 05.04.2012 International Filing Date: 28.09.2011
IPC:
C07C 401/00 (2006.01)
Applicants: WISCONSIN ALUMNI RESEARCH FOUNDATION [US/--]; 614 Walnut Street 13th Floor Madison, WI 53726 (US) (For All Designated States Except US).
DELUCA, Hector, F. [US/US]; (US) (For US Only).
GRZYWACZ, Pawel [PL/US]; (US) (For US Only).
THODEN, James, B. [US/US]; (US) (For US Only).
HOLDEN, Hazel [US/US]; (US) (For US Only)
Inventors: DELUCA, Hector, F.; (US).
GRZYWACZ, Pawel; (US).
THODEN, James, B.; (US).
HOLDEN, Hazel; (US)
Agent: WONZY, Thomas, M.; Andrus, Sceales, Starke & Sawall LLP 100 East Wisconsin Avenue Suite 1100 Milwaukee, WI 53202 (US)
Priority Data:
61/388,536 30.09.2010 US
Title (EN) (20R,25S)-2-METHYLENE-19,26-DINOR-1α, 25-DIHYDROXYVITAMIN D3 IN CRYSTALLINE FORM
(FR) (20R,25S)-2-MÉTHYLÈNE-L9,26-DINOR-LΑ,25-DIHYDROXYVITAMINE D3 SOUS FORME CRISTALLINE
Abstract: front page image
(EN)A method of purifying (20R,25S)-2-methylene-l9,26-dinor-lα,25-dihydroxyvitamin D3 to obtain (20R,25S)-2-methylene-l9,26-dinor-lα,25-dihydroxyvitamin D3 in crystalline form. The method includes the steps of preparing a solvent of methanol and water, dissolving a product containing (20R,25S)-2-methylene-19,26-dinor-lα,25-dihydroxyvitamin D3 to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of (20R,25S)-2-methylene-19,26-dinor-lα,25-dihydroxyvitamin D3 crystals, and recovering the (20R,25S)-2-methylene-19,26-dinor-la,25-dihydroxyvitamin D3 crystals.
(FR)La présente invention concerne un procédé de purification de la (20R,25S)-2-méthylène-l9,26-dinor-lα,25-dihydroxyvitamine D3 en vue de l'obtention de (20R,25S)-2-méthylène-l9,26-dinor-lα,25-dihydroxyvitamine D3 sous forme cristalline. Ledit procédé comprend les étapes consistant à préparer un solvant à base de méthanol et d'eau, à dissoudre un produit contenant de la (20R,25S)-2-méthylène-l9,26-dinor-lα,25-dihydroxyvitamine D3 à purifier dans le solvant, à refroidir le solvant et le produit dissous jusqu'à une température inférieure à la température ambiante et ce, pendant une durée suffisante pour faire précipiter la (20R,25S)-2-méthylène-l9,26-dinor-lα,25-dihydroxyvitamine D3 sous forme de cristaux, puis à recueillir lesdits cristaux de (20R,25S)-2-méthylène-l9,26-dinor-lα,25-dihydroxyvitamine D3.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)