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1. (WO2012044189) A NEW HYDRATED CRYSTALLINE FORM OF PERINDOPRIL ERBUMINE, METHODS FOR ITS PREPARATION AND ITS USE IN PHARMACEUTICAL PREPARATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/044189    International Application No.:    PCT/PT2011/000033
Publication Date: 05.04.2012 International Filing Date: 26.09.2011
IPC:
C07D 209/42 (2006.01), A61K 31/405 (2006.01), A61P 9/12 (2006.01)
Applicants: INSTITUTO SUPERIOR TÉCNICO [PT/PT]; Avenida Rovisco Pais 1049-001 Lisboa (PT) (For All Designated States Except US).
DUARTE, María Teresa Nogueira Leal da Silva [PT/PT]; (PT) (For US Only).
ANDRÉ, Vânia Mafalda de Oliveira [PT/PT]; (PT) (For US Only).
SILVA, Luís Manuel Cunha [PT/PT]; (PT) (For US Only).
SANTOS, Pedro Paulo de Lacerda e Oliveira [PT/PT]; (PT) (For US Only).
EMPIS, José Manuel Abecassis [PT/PT]; (PT) (For US Only)
Inventors: DUARTE, María Teresa Nogueira Leal da Silva; (PT).
ANDRÉ, Vânia Mafalda de Oliveira; (PT).
SILVA, Luís Manuel Cunha; (PT).
SANTOS, Pedro Paulo de Lacerda e Oliveira; (PT).
EMPIS, José Manuel Abecassis; (PT)
Common
Representative:
INSTITUTO SUPERIOR TÉCNICO [PT/PT]; Avenida Rovisco Pais 1049-001 Lisboa (PT)
Priority Data:
105315 29.09.2010 PT
Title (EN) A NEW HYDRATED CRYSTALLINE FORM OF PERINDOPRIL ERBUMINE, METHODS FOR ITS PREPARATION AND ITS USE IN PHARMACEUTICAL PREPARATIONS
(FR) FORME CRISTALLINE HYDRATÉE INÉDITE DE L'ERBUMINE DE PÉRINDOPRIL, SES PROCÉDÉS DE PRÉPARATION ET SON UTILISATION DANS DES PRÉPARATIONS PHARMACEUTIQUES
Abstract: front page image
(EN)The object of this invention is a new hydrated form of perindopril erbumine (I) characterized by different techniques, including powder and single crystal X-ray diffraction, being useful in the preparation of pharmaceutical compounds. This new form may be obtained by crystallization from an alcoholic solution or directly by grinding of other crystalline forms. All the synthetic pathways described lead to new form starting from any of the perindopril erbumine polymorphic forms.
(FR)La présente invention concerne une forme hydratée inédite de l'erbumine de périndopril (I), caractérisée par différentes techniques, dont la diffraction des rayons X sur poudre et la diffraction des rayons X sur un cristal unique. Ladite forme hydratée inédite peut être utilisée dans le cadre de la préparation de composés pharmaceutiques. Elle peut être obtenue par cristallisation à partir d'une solution alcoolique ou directement par broyage d'autres formes cristallines. Toutes les voies de synthèse décrites permettent l'obtention de ladite forme inédite à partir de l'une quelconque des formes polymorphes de l'erbumine de périndopril.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)