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1. (WO2012043820) METHOD AND DEVICE FOR MYOCARDIAL CELL EVALUATION AND MYOCARDIAL TOXICITY INSPECTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/043820    International Application No.:    PCT/JP2011/072618
Publication Date: 05.04.2012 International Filing Date: 30.09.2011
IPC:
C12M 1/34 (2006.01), C12Q 1/02 (2006.01)
Applicants: NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY [JP/JP]; 5-45, Yushima 1-chome, Bunkyo-ku, Tokyo 1138510 (JP) (For All Designated States Except US).
MITSUBISHI CHEMICAL MEDIENCE CORPORATION [JP/JP]; 2-8, Shibaura 4-chome, Minato-ku, Tokyo 1088559 (JP) (For All Designated States Except US).
YASUDA Kenji [JP/JP]; (JP) (For US Only).
KANEKO Tomoyuki [JP/JP]; (JP) (For US Only).
NOMURA Fumimasa [JP/JP]; (JP) (For US Only)
Inventors: YASUDA Kenji; (JP).
KANEKO Tomoyuki; (JP).
NOMURA Fumimasa; (JP)
Agent: KOBAYASHI Hiroshi; ABE, IKUBO & KATAYAMA, Fukuoka Bldg. 9th Fl., 8-7, Yaesu 2-chome, Chuo-ku, Tokyo 1040028 (JP)
Priority Data:
2010-222636 30.09.2010 JP
2010-234498 19.10.2010 JP
2011-090536 14.04.2011 JP
Title (EN) METHOD AND DEVICE FOR MYOCARDIAL CELL EVALUATION AND MYOCARDIAL TOXICITY INSPECTION
(FR) PROCÉDÉ ET DISPOSITIF D'ÉVALUATION DE CELLULES MYOCARDIQUES ET CONTRÔLE DE LA TOXICITÉ MYOCARDIQUE
(JA) 心筋毒性検査および心筋細胞評価のための方法および装置
Abstract: front page image
(EN)In the present invention, a myocardial cell cluster is disposed on a transparent substrate, and the quality of the myocardial cells is evaluated from the response of the cells to a forced pulsation stimulus applied to the cardiomyocytes. The myocardial cell cluster is disposed on the transparent substrate, and is exposed to the flow of a liquid containing a drug in a manner so that the drug acts on the cells, which configure a network. The extent of cardiac toxicity resulting from the drug is evaluated from measuring the fluctuations obtained from a comparison of adjacent cardimyocytes of the network.
(FR)Dans la présente invention, un amas de cellules myocardiques est disposé sur un substrat transparent. La qualité des cellules myocardiques est évaluée à partir de la réponse de ces cellules à un stimulus de pulsations forcées appliqué au cardiomyocytes. L'amas de cellules myocardiques disposé sur un substrat transparent est exposé à un flux de liquide contenant un médicament de telle sorte que le médicament agisse sur les cellules qui forment un réseau. L'ampleur de la toxicité cardiaque due au médicalement est évaluée à partir des fluctuations obtenues à partir d'une comparaison entre cardiomyocytes du réseau.
(JA) 透明基板上に心筋細胞集団を配置し、心筋拍動細胞に与えた強制拍動刺激に対する心筋細胞の応答から心筋細胞の品質を評価する。透明基板上に心筋細胞集団を配置し、ネットワークを構成する細胞には薬物が作用するように薬物を含む液体の流れに曝す。ネットワークの隣接する心筋拍動細胞の比較から得られるゆらぎ計測から薬物による心毒性の程度を評価する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)