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1. WO2012043801 - PATCH

Publication Number WO/2012/043801
Publication Date 05.04.2012
International Application No. PCT/JP2011/072579
International Filing Date 30.09.2011
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
70
Web, sheet or filament bases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
14
Esters of carboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
38
Cellulose; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61K 31/445 (2006.01)
A61K 9/70 (2006.01)
A61K 47/14 (2006.01)
A61K 47/38 (2006.01)
A61P 25/28 (2006.01)
CPC
A61K 31/445
A61K 47/10
A61K 47/14
A61K 47/32
A61K 47/38
A61K 9/7061
Applicants
  • 積水メディカル株式会社 SEKISUI MEDICAL Co.,Ltd. [JP/JP]; 東京都中央区日本橋3丁目13番5号 13-5, Nihombashi 3-chome, Chuo-ku, Tokyo 1030027, JP (AllExceptUS)
  • 薦田 俊一 KOMODA Toshikazu [JP/JP]; JP (UsOnly)
  • 野田 幸彦 NODA Yukihiko [JP/JP]; JP (UsOnly)
Inventors
  • 薦田 俊一 KOMODA Toshikazu; JP
  • 野田 幸彦 NODA Yukihiko; JP
Agents
  • 山本 拓也 YAMAMOTO Takuya; 大阪府大阪市阿倍野区昭和町1丁目21番22号 徳山ビル201号 Tokuyama Bldg.201, 21-22, Showa-cho 1-chome, Abeno-ku, Osaka-shi, Osaka 5450011, JP
Priority Data
2010-22299830.09.2010JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) PATCH
(FR) PATCH
(JA) 貼付剤
Abstract
(EN)
The present invention provides a patch which shows excellent storage stability of donepezil or a salt thereof and enables stable transdermal administration of donepezil or a salt thereof in a pharmacologically effective dose. This patch is characterized by comprising a substrate (1) and a pressure-sensitive adhesive layer (2), said pressure-sensitive adhesive layer (2) being laminated and integrated on one surface of the substrate (1) and containing donepezil or a salt thereof together with an acrylic pressure-sensitive adhesive comprising a copolymer which is obtained by copolymerizing a monomer containing an ester of a saturated aliphatic alcohol and (meth)acrylic acid and being vinylpyrrolidone-free.
(FR)
La présente invention concerne un patch qui présente une excellente stabilité de stockage du donépézil ou de l'un de ses sels et qui permet une administration transdermique stable de donépézil ou de l'un de ses sels dans une dose pharmacologiquement efficace. Ce patch est caractérisé en ce qu'il comprend un substrat (1) et une couche adhésive sensible à la pression (2), ladite couche adhésive sensible à la pression (2) étant laminée et intégrée sur une surface du substrat (1) et contenant du donépézil ou l'un de ses sels conjointement avec un adhésif acrylique sensible à la pression comprenant un copolymère obtenu par copolymérisation d'un monomère à base d'un ester d'un alcool aliphatique saturé et d'un acide (méth)acrylique et étant dépourvu de vinylpyrrolidone.
(JA)
 本発明は、ドネペジル又はその塩の保存安定性に優れ且つドネペジル又はその塩を薬効が得られる量でもって安定的に経皮投与することができる貼付剤を提供する。本発明の貼付剤は、支持体1と、この支持体1の一面に積層一体化され、且つ、飽和脂肪族アルコールと(メタ)アクリル酸とのエステルを含有し且つビニルピロリドンを含有しない単量体を共重合してなる共重合体を含有するアクリル系粘着剤と、ドネペジル又はその塩とを含む粘着剤層2とを含むことを特徴とする。
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