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1. (WO2012043701) TRANSDERMAL ABSORPTION PREPARATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/043701    International Application No.:    PCT/JP2011/072334
Publication Date: 05.04.2012 International Filing Date: 29.09.2011
IPC:
A61K 31/445 (2006.01), A61K 9/06 (2006.01), A61K 9/08 (2006.01), A61K 9/70 (2006.01), A61K 47/10 (2006.01), A61K 47/12 (2006.01), A61K 47/14 (2006.01)
Applicants: TOYAMA CHEMICAL CO., LTD. [JP/JP]; 2-5, Nishishinjuku 3-chome, Shinjuku-ku Tokyo 1600023 (JP) (For All Designated States Except US).
KUBO, Yoshiko [JP/JP]; (JP) (For US Only).
KOUNO, Ryoji [JP/JP]; (JP) (For US Only).
YOSHIMURA, Misaki [JP/JP]; (JP) (For US Only).
JO, Rumi [JP/JP]; (JP) (For US Only)
Inventors: KUBO, Yoshiko; (JP).
KOUNO, Ryoji; (JP).
YOSHIMURA, Misaki; (JP).
JO, Rumi; (JP)
Priority Data:
2010-221604 30.09.2010 JP
2011-064431 23.03.2011 JP
Title (EN) TRANSDERMAL ABSORPTION PREPARATION
(FR) PRÉPARATION POUR ABSORPTION TRANSDERMIQUE
(JA) 経皮吸収製剤
Abstract: front page image
(EN)Disclosed is a safe, transdermal absorption preparation useful in the treatment of fungal infections, having excellent skin permeability and strong antifungal activity, and greatly contributing to a patient's quality of life. The disclosed transdermal absorption preparation contains 4-{3-[4-(3-{4-[amino (imino) methyl] phenoxy} propyl)-1-piperidinyl] propoxy} benzamidine, or a salt thereof, and a transdermal absorption enhancer.
(FR)L'invention concerne une préparation pour absorption transdermique sûre, utile dans le traitement des infections fongiques, présentant une excellente perméabilité cutanée et une forte activité antifongique et améliorant considérablement la qualité de vie des patients. La préparation selon l'invention contient 4-{3-[4-(3-{4-[amino(imino)méthyl]phénoxy}profil)-1-pipéridinyl]propoxy}benzamidine, ou un sel de ce composé, ainsi qu'un activateur d'absorption transdermique.
(JA) 4-{3-[4-(3-{4-[アミノ(イミノ)メチル]フェノキシ}プロピル)-1-ピペリジニル]プロポキシ}ベンズアミジンまたはその塩、および、経皮吸収促進剤を含有する経皮吸収製剤は、優れた皮膚透過性を有し、強い抗真菌活性を有し、患者のクオリティーオブライフを大きく改善でき、安全性に優れ、真菌感染症の治療に有用である。 
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)