WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012043481) COMPOSITION CONTAINING 2-ACYL-LYSOPHOSPHATIDYLSERINE AND METHOD FOR PRODUCING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/043481    International Application No.:    PCT/JP2011/071900
Publication Date: 05.04.2012 International Filing Date: 26.09.2011
IPC:
C12P 7/64 (2006.01), A61K 31/685 (2006.01), A61P 25/00 (2006.01)
Applicants: National University Corporation Tokyo University of Marine Science and Technology [JP/JP]; 5-7, Konan 4-chome, Minato-ku, Tokyo 1088477 (JP) (For All Designated States Except US).
Meiji Co., Ltd. [JP/JP]; 2-10, Shinsuna 1-chome, Koto-ku, Tokyo 1368908 (JP) (For All Designated States Except US).
YAZAWA Kazunaga [JP/JP]; (JP) (For US Only).
SUSA Tomoyuki [JP/JP]; (JP) (For US Only).
GOTOH Shoji [JP/JP]; (JP) (For US Only).
TASHIRO Yasuhito [JP/JP]; (JP) (For US Only).
KAWASHIMA Junichi [JP/JP]; (JP) (For US Only).
IMAMURA Shigeyuki [JP/JP]; (JP) (For US Only)
Inventors: YAZAWA Kazunaga; (JP).
SUSA Tomoyuki; (JP).
GOTOH Shoji; (JP).
TASHIRO Yasuhito; (JP).
KAWASHIMA Junichi; (JP).
IMAMURA Shigeyuki; (JP)
Agent: HASEGAWA Yoshiki; SOEI PATENT AND LAW FIRM, Marunouchi MY PLAZA (Meiji Yasuda Life Bldg.) 9th fl., 1-1, Marunouchi 2-chome, Chiyoda-ku, Tokyo 1000005 (JP)
Priority Data:
2010-220880 30.09.2010 JP
Title (EN) COMPOSITION CONTAINING 2-ACYL-LYSOPHOSPHATIDYLSERINE AND METHOD FOR PRODUCING SAME
(FR) COMPOSITION CONTENANT DE LA 2-ACYL-LYSOPHOSPHATIDYLSÉRINE ET SON PROCÉDÉ DE PRODUCTION
(JA) 2-アシル-リゾホスファチジルセリン含有組成物及びその製造方法
Abstract: front page image
(EN)The present invention provides a method for producing a composition containing 2-acyl-lysophosphatidylserine, the method comprising: (a) a step for obtaining a composition containing phosphatidylserine by causing phospholipase D to act on a starting material containing phosphatidylcholine while in the presence of serine; and (b) a step for obtaining a composition containing 2-acyl-lysophosphatidylserine by causing phospholipase A1 to act on the composition containing phosphatidylserine while in the presence of at least one type of additive selected from a group consisting of (I), (II), and (III). (I) represents at least one monovalent cationic salt selected from a group consisting of sulfates, phosphates, nitrates, citrates and tartrates, (II) represents a gum, and (III) represents an emulsifier.
(FR)La présente invention concerne un procédé de production d'une composition contenant de la 2-acyl-lysophosphatidylsérine, le procédé comprenant : une étape (a) d'obtention d'une composition contenant de la phosphatidylsérine en faisant agir la phospholipase D sur une matière première contenant de la phosphatidylcholine, en présence de sérine ; et une étape (b) d'obtention d'une composition contenant de la 2-acyl-lysophosphatidylsérine en faisant agir la phospholipase A1 sur une matière première contenant de la phosphatidylsérine, en présence d'au moins un type d'additif choisi dans un groupe consistant en (I), (II) et (III). (I) représente au moins un sel d'un cation monovalent choisi dans un groupe constitué des sulfates, phosphates, nitrates, citrates et tartrates, (II) représente une gomme et (III) représente un émulsifiant.
(JA)本発明は、2-アシル-リゾホスファチジルセリン含有組成物の製造方法であって、(a)ホスファチジルコリンを含有する原料に、セリン存在下でホスホリパーゼDを作用させて、ホスファチジルセリンを含有する組成物を得る工程と、(b)ホスファチジルセリンを含有する組成物に、下記の(I)、(II)及び(III)からなる群から選択される一種以上の添加剤の存在下でホスホリパーゼA1を作用させて、2-アシル-リゾホスファチジルセリンを含有する組成物を得る工程と、を含み、(I)は、1価のカチオンの、硫酸塩、リン酸塩、硝酸塩、クエン酸塩及び酒石酸塩からなる群より選択される一種以上の塩であり、(II)は、ガム類であり、(III)は、乳化剤である、方法を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)