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1. (WO2012042502) DIAZARIDINE DERIVATIVES FOR TREATING METAL DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/042502    International Application No.:    PCT/IB2011/054304
Publication Date: 05.04.2012 International Filing Date: 29.09.2011
IPC:
C07D 229/02 (2006.01), A61K 31/336 (2006.01), A61P 25/24 (2006.01)
Applicants: PHARMDISCOVERY LLP [GB/GB]; 23-24 Great James Street, Suite 2 London WC1N 3ES (GB) (For All Designated States Except US).
PETUKHOVA, Vera, Yur'evna [RU/RU]; (RU) (For US Only).
NOVAKOVSKIY, Vladimir, Vladimirovich [RU/RU]; (RU) (For US Only).
MAKHOVA, Nina, Nikolayevna [RU/RU]; (RU) (For US Only).
SHEVTSOV, Alexander, Vladimirovich [RU/RU]; (RU)
Inventors: PETUKHOVA, Vera, Yur'evna; (RU).
NOVAKOVSKIY, Vladimir, Vladimirovich; (RU).
MAKHOVA, Nina, Nikolayevna; (RU).
SHEVTSOV, Alexander, Vladimirovich; (RU)
Priority Data:
61/387,844 29.09.2010 US
Title (EN) DIAZARIDINE DERIVATIVES FOR TREATING METAL DISORDERS
(FR) DÉRIVÉS DE DIAZARIDINE UTILES DANS LE TRAITEMENT DES TROUBLES MENTAUX
Abstract: front page image
(EN)The present invention relates to compounds of formula (I) or (la), use of these compounds to treat mental disorders, especially depressions of different etiology, and methods for their preparation. The compounds that are provided for the treatment of mental disorders can be presented by a general formula (I) as meso-form -S,2S,1'R,2'R-1-[ω-(3,3-dialkyldiaziridin-1-yl)alkyl] -3,3-dialkyldiaziridines: wherein R, X and n are as defined in specification or pharmaceutically acceptable salts thereof, solvates thereof such as hydrates, and pharmaceutical compositions containing such compounds, with the proviso that the compound of Formula (I) is not meso-1S,2S,1'R,2'R-1-[2-(3,3-dimethyldiaziridin-1-yl)ethyl]-3,3-dimethyldiaziridine (R=Me, X=CH2, n=2) (Formula la).
(FR)L'invention concerne des composés de formule (I) ou (la), l'utilisation de ces composés dans le traitement des troubles mentaux, en particulier de dépressions d'étiologies diverses, ainsi que des procédés de préparation associés. Les composés selon l'invention peuvent être représentés par une formule générale (I) de mésoformes -S,2S,1'R,2'R-1-[ω-(3,3-dialkyldiaziridin-1-yl)alkyl]-3,3-dialkyldiaziridines : dans laquelle R, X et n sont tels que définis dans la description. L'invention concerne également des sels pharmaceutiquement acceptables de ces composés, des solvates de ceux-ci, tels que des hydrates, ainsi que des compositions pharmaceutiques contenant ces composés, à condition que le composé de Formule (I) ne soit pas méso-1S,2S,1'R,2'R-1-[2-(3,3-diméthyldiaziridin-1-yl)éthyl]-3,3-diméthyldiaziridine (R=Me, X=CH2, n=2) (Formule la).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)