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Machine translation
1. (WO2012042386) MANNOSIDASES CAPABLE OF UNCAPPING MANNOSE-1-PHOSPHO-6-MANNOSE LINKAGES AND DEMANNOSYLATING PHOSPHORYLATED N-GLYCANS AND METHODS OF FACILITATING MAMMALIAN CELLULAR UPTAKE OF GLYCOPROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/042386    International Application No.:    PCT/IB2011/002770
Publication Date: 05.04.2012 International Filing Date: 29.09.2011
Chapter 2 Demand Filed:    30.07.2012    
IPC:
C12P 19/26 (2006.01), C12P 21/00 (2006.01), A61K 38/43 (2006.01), C12N 9/10 (2006.01), C12N 15/81 (2006.01)
Applicants: OXYRANE UK LIMITED [GB/GB]; Greenheys House, Manchester Science Park 10 Pencroft Way Manchester M15 6JJ (GB) (For All Designated States Except US).
PYNAERT, Gwenda, Noella [BE/BE]; (BE) (For US Only).
PIENS, Kathleen Camilla, Telesphore Alida Maria [BE/BE]; (BE) (For US Only).
VALEVSKA, Albena, Vergilieva [BE/BE]; (BE) (For US Only).
VERVECKEN, Wouter [BE/BE]; (BE) (For US Only)
Inventors: PYNAERT, Gwenda, Noella; (BE).
PIENS, Kathleen Camilla, Telesphore Alida Maria; (BE).
VALEVSKA, Albena, Vergilieva; (BE).
VERVECKEN, Wouter; (BE)
Priority Data:
61/387,940 29.09.2010 US
61/477,014 19.04.2011 US
Title (EN) MANNOSIDASES CAPABLE OF UNCAPPING MANNOSE-1-PHOSPHO-6-MANNOSE LINKAGES AND DEMANNOSYLATING PHOSPHORYLATED N-GLYCANS AND METHODS OF FACILITATING MAMMALIAN CELLULAR UPTAKE OF GLYCOPROTEINS
(FR) MANNOSIDASES CAPABLES D'ÉLIMINER LA COIFFE DES LIAISONS MANNOSE-1-PHOSPHO- 6-MANNOSE ET DE DÉMANNOSYLER LES N-GLYCANES PHOSPHORYLÉS, ET MÉTHODES FACILITANT L'ASSIMILATION DES GLYCOPROTÉINES PAR DES CELLULES DE MAMMIFÈRES
Abstract: front page image
(EN)The invention provides mannosidases capable of uncapping mannose-l-phospho- 6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
(FR)Cette invention concerne des mannosidases capables d'éliminer la coiffe de fragments mannose-1-phospho-6-mannose et de démannosyler les N-glycanes phosphorylés, des procédés d'utilisation desdites mannosidases, des glycoprotéines produites par ces procédés, ainsi que des méthodes facilitant l'assimilation des glycoprotéines par des cellules de mammifères.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)