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1. (WO2012042038) CHIMERIC PEPTIDES INCLUDING A PENETRATING PEPTIDE AND A BINDING DOMAIN OF PP2A CATALYTIC SUBUNIT TO CASPASE-9
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/042038    International Application No.:    PCT/EP2011/067173
Publication Date: 05.04.2012 International Filing Date: 30.09.2011
IPC:
C07K 14/47 (2006.01), A61K 38/17 (2006.01)
Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR/FR]; 101, Rue de Tolbiac F-75013 Paris (FR) (For All Designated States Except US).
REBOLLO GARCIA, Angelita [ES/FR]; (FR) (For US Only).
DECAUDIN, Didier [FR/FR]; (FR) (For US Only).
NEMATI, Fariba [FR/FR]; (FR) (For US Only).
INSTITUT CURIE [FR/FR]; 26 rue d'Ulm F-75248 Paris cedex 05 (FR) (For All Designated States Except US)
Inventors: REBOLLO GARCIA, Angelita; (FR).
DECAUDIN, Didier; (FR).
NEMATI, Fariba; (FR)
Agent: BLOT, Philippe; Cabinet Lavoix 2, Place d'Estienne d'Orves F-75441 Paris Cedex 09 (FR)
Priority Data:
10306059.6 30.09.2010 EP
Title (EN) CHIMERIC PEPTIDES INCLUDING A PENETRATING PEPTIDE AND A BINDING DOMAIN OF PP2A CATALYTIC SUBUNIT TO CASPASE-9
(FR) PEPTIDES CHIMÉRIQUES COMPRENANT UN PEPTIDE DE PÉNÉTRATION ET UN DOMAINE DE LIAISON DE LA SOUS-UNITÉ CATALYTIQUE DE LA PP2A À LA CAPSASE 9
Abstract: front page image
(EN)The invention related to chimeric peptides including a penetrating peptide and a binding domain of PP2A catalytic subunit to caspase-9 which have pro-apoptotic activity. These chimeric peptides may be used for the treatment of hyperproliferative disorders.
(FR)L'invention concerne des peptides chimériques comprenant un peptide de pénétration et un domaine de liaison de la sous-unité catalytique de la PP2A à la capsase 9, qui présentent une activité pro-apoptotique. Lesdits peptides chimériques s'utilisent dans le traitement de troubles hyperprolifératifs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)