WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2012042024) SELF-ASSEMBLING NANOPARTICLES FOR THE RELEASE OF BISPHOSPHONATES IN THE TREATMENT OF HUMAN CANCERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/042024    International Application No.:    PCT/EP2011/067119
Publication Date: 05.04.2012 International Filing Date: 30.09.2011
Chapter 2 Demand Filed:    01.08.2012    
IPC:
A61K 47/48 (2006.01), A61P 35/00 (2006.01)
Applicants: DE ROSA, Giuseppe [IT/IT]; (IT).
CARAGLIA, Michele [IT/IT]; (IT).
ISTITUTI FISIOTERAPICI OSPITALIERI [IT/IT]; Via Elio Chianesi 53 I-00144 Roma (IT) (For All Designated States Except US).
TASSONE, Pierfrancesco [IT/IT]; (IT).
LA ROTONDA, Maria Immacolata [IT/IT]; (IT).
ABBRUZZESE SACCARDI, Alberto [IT/IT]; (IT).
SALZANO, Giuseppina [IT/IT]; (IT) (For US Only).
MARRA, Monica [IT/IT]; (IT) (For US Only).
LEONETTI, Carlo [IT/IT]; (IT) (For US Only)
Inventors: DE ROSA, Giuseppe; (IT).
CARAGLIA, Michele; (IT).
TASSONE, Pierfrancesco; (IT).
LA ROTONDA, Maria Immacolata; (IT).
ABBRUZZESE SACCARDI, Alberto; (IT).
SALZANO, Giuseppina; (IT).
MARRA, Monica; (IT).
LEONETTI, Carlo; (IT)
Agent: VALENZA, Silvia; Corso di Porta Vittoria 9 I-20122 Milano (IT)
Priority Data:
FI2010A000206 01.10.2010 IT
Title (EN) SELF-ASSEMBLING NANOPARTICLES FOR THE RELEASE OF BISPHOSPHONATES IN THE TREATMENT OF HUMAN CANCERS
(FR) NANOPARTICULES AUTO-ASSEMBLANTES POUR LA LIBÉRATION DE BISPHOSPHONATES DANS LE TRAITEMENT DES CANCERS HUMAINS
Abstract: front page image
(EN)The present invention descrive nanocomplexes also called auto-assembling nanoparticles comprisingbiphosphonates, lipid nanovectors and inorganic nanovectors. In particular the invention describes zoledronic acid complexed with calcium phosphate base nanoparticles; said particles in their turn mixed with lipidic particles e.g. liposomes. Said nanocomplexes are useful, and showed to be be efficient in vivo, as pharmaceutical formulations of biphosphonates for the treatment or prevention of tumor growth and/or metastasis. Tumors can be solidsand/or haematological such as prostate, lung, head/neck, colon, liver, breast, pancreas, kidneys, bladder, male and female urogenital tract, bones, multiple myeloma, primitive and secondary tumours of the central nervous system and lymphomas.
(FR)La présente invention concerne des nanocomplexes également appelés nanoparticules auto-assemblantes comprenant des biphosphonates, des nanovecteurs lipidiques et des nanovecteurs inorganiques. L'invention concerne en particulier de l'acide zolédronique complexé avec des nanoparticules à base de phosphate de calcium; lesdites particules sont à leur tour mélangées à des particules lipidiques, par exemple des liposomes. Lesdits nanocomplexes sont utiles et se sont révélés efficaces in vivo comme préparations pharmaceutiques de biphosphonates pour le traitement ou la prévention de la croissance tumorale et/ou des métastases. Les tumeurs peuvent être solides et/ou hématologiques, comme dans le cas de la prostate, du poumon, de la tête/du cou, du colon, du foie, du sein, du pancréas, des reins, de la vessie, du tractus urogénital, des os, des myélomes multiples, des tumeurs primitives et secondaires du système neveux central et des lymphomes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)