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1. (WO2012042020) GLYSCOSYLATION MARKERS FOR THE DIAGNOSIS OF MATURITY ONSET DIABETES OF THE YOUNG
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/042020    International Application No.:    PCT/EP2011/067112
Publication Date: 05.04.2012 International Filing Date: 30.09.2011
IPC:
G01N 33/68 (2006.01), G01N 33/53 (2006.01)
Applicants: CAMPBELL, Harry [GB/GB]; (GB) (For US Only).
RUDAN, Igor [HR/GB]; (GB) (For US Only).
WRIGHT, Alan F. [GB/GB]; (GB) (For US Only).
KATTLA, Jayesh Jagunnathan [IN/IE]; (IE) (For US Only).
RUDD, Pauline [GB/IE]; (IE) (For US Only).
LAUC, Gordan [HR/HR]; (HR) (For US Only).
THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH [GB/GB]; Old College South Bridge Edinburgh EH8 9YL (GB) (For All Designated States Except US).
NATIONAL INSTITUTE FOR BIOPROCESSING RESEARCH AND TRAINING LIMITED [IE/IE]; Fosters Avenue Mount Merrion Blackrock Co Dublin (IE) (For All Designated States Except US).
GENOS LTD [HR/HR]; Planinska 1 Zagreb 10000 Zagreb (HR) (For All Designated States Except US)
Inventors: CAMPBELL, Harry; (GB).
RUDAN, Igor; (GB).
WRIGHT, Alan F.; (GB).
KATTLA, Jayesh Jagunnathan; (IE).
RUDD, Pauline; (IE).
LAUC, Gordan; (HR)
Agent: CARR, Anne Marie; Murgitroyd & Company Scotland House, 165-169 Scotland Street Glasgow Strathclyde G5 8PL (GB)
Priority Data:
1016464.8 30.09.2010 GB
Title (EN) GLYSCOSYLATION MARKERS FOR THE DIAGNOSIS OF MATURITY ONSET DIABETES OF THE YOUNG
(FR) MARQUEURS DE GLYCOSYLATION DESTINÉS AU DIAGNOSTIC DU DIABÈTE DE LA MATURITÉ CHEZ UN SUJET JEUNE
Abstract: front page image
(EN)A method for diagnosing Maturity-Onset Diabetes of the Young (MODY) in a subject is provided. The method comprises providing a glycan- containing test sample from the subject; determining one or more levels of fucosylation of the glycans in the test sample; comparing the one or more levels of fucosylation with one or more reference values; and providing a diagnosis based on said comparison. This method may be used to distinguish HNF1A-MODY or HNF4A-MODY from other types of diabetes such that the correct treatment may be prescribed for the subject.
(FR)La présente invention concerne un procédé de diagnostic du diabète de la maturité chez un sujet jeune (MODY). Le procédé comprend la fourniture d'un échantillon de test contenant des glycanes prélevé sur le sujet ; la détermination d'un ou de plusieurs niveaux de fucosylation des glycanes dans l'échantillon de test ; la comparaison du ou des niveaux de fucosylation à une ou plusieurs valeurs de référence ; et la fourniture d'un diagnostic basé sur ladite comparaison. Ce procédé peut être utilisé pour différencier le MODY HNF1A et le MODY HNF4A d'autres types de diabètes de manière à ce que le traitement adapté puisse être prescrit au sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)