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1. (WO2012041493) AMINOQUINOLINIUM SALTS, METHODS OF THEIR PRODUCTION AND THEIR USE AS ACTIVE AGENTS FOR BIOTECHNOLOGICAL AND MEDICAL APPLICATIONS AGAINST BINARY TOXINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/041493    International Application No.:    PCT/EP2011/004846
Publication Date: 05.04.2012 International Filing Date: 28.09.2011
IPC:
C07D 215/42 (2006.01), C07D 215/46 (2006.01), C07D 401/06 (2006.01), A61K 31/4706 (2006.01), A61K 31/4709 (2006.01), A61P 31/00 (2006.01)
Applicants: JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG [DE/DE]; Sanderring 2 97070 Würzburg (DE) (For All Designated States Except US).
UNIVERSITÄT ULM [DE/DE]; Helmholtzstr. 16 89081 UIm (DE) (For All Designated States Except US).
BRINGMANN, Gerhard [DE/DE]; (DE) (For US Only).
LÖDIGE, Melanie [DE/DE]; (DE) (For US Only).
KRONHARDT, Angelika [DE/DE]; (DE) (For US Only).
BEITZINGER, Christoph [DE/DE]; (DE) (For US Only).
BARTH, Holger [DE/DE]; (DE) (For US Only).
BENZ, Roland [DE/DE]; (DE) (For US Only)
Inventors: BRINGMANN, Gerhard; (DE).
LÖDIGE, Melanie; (DE).
KRONHARDT, Angelika; (DE).
BEITZINGER, Christoph; (DE).
BARTH, Holger; (DE).
BENZ, Roland; (DE)
Agent: ENGELHARD, Markus; BOEHMERT & BOEHMERT Hollerallee 32 D-28209 Bremen (DE)
Priority Data:
10011269.7 28.09.2010 EP
Title (EN) AMINOQUINOLINIUM SALTS, METHODS OF THEIR PRODUCTION AND THEIR USE AS ACTIVE AGENTS FOR BIOTECHNOLOGICAL AND MEDICAL APPLICATIONS AGAINST BINARY TOXINS
(FR) SELS D'AMINOQUINOLINE, LEURS PROCÉDÉS DE PRODUCTION ET LEUR UTILISATION EN TANT QU'AGENTS ACTIFS POUR DES APPLICATIONS BIOTECHNOLOGIQUES ET MÉDICALES CONTRE LES TOXINES BINAIRES
Abstract: front page image
(EN)The present invention relates to aminoquinoline salts, their uses and to methods of synthesizing such aminoquinoline salts. Moreover, the present invention relates to compositions comprising aminoquinoline salts in accordance with the present invention. The present invention relates to bioactive compounds from the class of aminoquinoline compounds, and in particular their inhibitory effects on the binary toxins of an AB-type of a number of bacteria, such as Clostridium perfringens, Clostridium botulinum, and Bacillus anthracis. The invention also relates to the use of these aminoquinoline compounds as drugs, more particularly as drugs for the treatment of bacterial infections, even more particularly bacterial infections caused by bacteria which produce pore forming toxins of a binary type. The present invention also relates to methods of producing the compounds in accordance with the present invention.
(FR)La présente invention concerne des sels d'aminoquinoline, leurs utilisations et des procédés de synthèse de ces sels d'aminoquinoline. La présente invention concerne par ailleurs des compositions comprenant des sels d'aminoquinoline selon la présente invention. La présente invention concerne des composés bioactifs issus de la catégorie des composés d'aminoquinoline, et en particulier, leurs effets inhibiteurs sur les toxines binaires d'un type AB d'un certain nombre de bactéries, telles que Clostridium perfringens, Clostridium botulinum et Bacillus anthracis. L'invention concerne également l'utilisation de ces composés d'aminoquinoline comme médicaments, plus particulièrement, comme médicaments pour le traitement d'infections bactériennes, encore plus particulièrement, d'infections bactériennes causées par des bactéries qui produisent des toxines porogènes de type binaire. La présente invention concerne également des procédés de production des composés selon la présente invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)