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1. (WO2012040922) METHOD FOR PREPARING N2-[1-(S)-ETHOXYCARBONYL-3-PHENYLPROPYL]-N6- TRIFLUOROACETYL-L-LYSINE WITH HIGH OPTICAL PURITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/040922    International Application No.:    PCT/CN2010/077478
Publication Date: 05.04.2012 International Filing Date: 29.09.2010
IPC:
C07C 233/47 (2006.01), C07C 231/20 (2006.01)
Applicants: ABA CHEMICALS CORPORATION [CN/CN]; 18 Dongfang Rd(E), Port Development Zone Taicang, Jiangsu 215433 (CN) (For All Designated States Except US).
QUE, Limin [CN/CN]; (CN) (For US Only).
JIANG, Yueheng [CN/CN]; (CN) (For US Only).
LIN, Zhigang [CN/CN]; (CN) (For US Only).
CAI, Tong [CN/CN]; (CN) (For US Only)
Inventors: QUE, Limin; (CN).
JIANG, Yueheng; (CN).
LIN, Zhigang; (CN).
CAI, Tong; (CN)
Agent: NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHIP); Suite 1912 Longtaiguoji Mansion, No.198, Zhongshandonglu, Baixia District Nanjing, Jiangsu 210005 (CN)
Priority Data:
201010294700.8 28.09.2010 CN
Title (EN) METHOD FOR PREPARING N2-[1-(S)-ETHOXYCARBONYL-3-PHENYLPROPYL]-N6- TRIFLUOROACETYL-L-LYSINE WITH HIGH OPTICAL PURITY
(FR) MÉTHODE DE PRÉPARATION DE N2-[1-(S)-ÉTHOXYCARBONYL-3-PHÉNYLPROPYL]-N6-TRIFLUOROACÉTYL-L-LYSINE DE PURETÉ OPTIQUE ÉLEVÉE
(ZH) 一种具有高光学纯度的N2-[1-(S)-乙氧羰基-3-苯丙基]-N6-三氟乙酰基-L-赖氨酸的制备方法
Abstract: front page image
(EN)A method for preparing N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl -L-lysine is provided. The method comprises: adding crude N2-[1-(S)-ethoxy carbonyl-3-phenyl-propyl]-N6-trifluoroacetyl-L-lysine to an organic solvent, adding an organic acid, stirring, filtering, and then adding to deionized water, adding an inorganic base or organic base to adjust pH, filtering, washing and drying to obtain N2-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine product with high optical purity. With the method, the prepared product has high optical purity and 1S-isomer/1R-isomer is ≥99/1.
(FR)La présente invention concerne une méthode de préparation de la N2-[1-(S)-éthoxycarbonyl-3-phénylpropyl]-N6-trifluoroacétyl-L-lysine. La méthode comprend : l'ajout de N2-[1-(S)-éthoxycarbonyl-3-phényl-propyl]-N6-trifluoroacétyl-L-lysine brute à un solvant organique, l'ajout d'un acide organique, l'agitation, la filtration puis l'ajout à de l'eau déionisée, l'ajout d'une base inorganique ou d'une base organique pour ajuster le pH, la filtration, le lavage et le séchage pour obtenir le produit N2-[1-(S)-éthoxycarbonyl-3-phényl-propyl]-N6-trifluoroacétyl-L-lysine avec une pureté optique élevée. La méthode permet d'obtenir un produit préparé de pureté optique élevée et de rapport isomère 1S/isomère 1R supérieur ou égal à 99/1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)