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Machine translation
1. (WO2012040846) PROCESS FOR PREPARATION OF AMINOCYCLOHEXYL ETHERS AND INTERMEDIATE PRODUCTS USED IN THE PROCESS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2012/040846    International Application No.:    PCT/CA2011/050598
Publication Date: 05.04.2012 International Filing Date: 26.09.2011
IPC:
C07D 207/12 (2006.01)
Applicants: ALPHORA RESEARCH INC. [CA/CA]; Suite 2001 2395 Speakman Drive Mississauga, Ontario L5K 1B3 (CA) (For All Designated States Except US).
GORIN, Boris [CA/CA]; (CA) (For US Only).
DIXON, Craig Edward [CA/CA]; (CA) (For US Only).
OUDENES, Jan [CA/CA]; (CA) (For US Only).
BEJAN, Elena Valentina [CA/CA]; (CA) (For US Only).
KINSMAN, Aaron Cleveland [CA/CA]; (CA) (For US Only)
Inventors: GORIN, Boris; (CA).
DIXON, Craig Edward; (CA).
OUDENES, Jan; (CA).
BEJAN, Elena Valentina; (CA).
KINSMAN, Aaron Cleveland; (CA)
Agent: RIDOUT & MAYBEE LLP; 225 King Street West 10th Floor Toronto, Ontario M5V 3M2 (CA)
Priority Data:
61/386,830 27.09.2010 US
Title (EN) PROCESS FOR PREPARATION OF AMINOCYCLOHEXYL ETHERS AND INTERMEDIATE PRODUCTS USED IN THE PROCESS
(FR) PROCÉDÉ DE PRÉPARATION D'AMINOCYCLOHEXYLE ÉTHERS ET PRODUITS INTERMÉDIAIRES UTILISÉS DANS LE PROCÉDÉ
Abstract: front page image
(EN)A process for preparation of a compound of formula (I) or or a pharmaceutically acceptable salt, ester, or prodrug thereof, is disclosed. The process involves hydrogenating, in the presence of a catalyst, a compound of formula (II). The different substituents are as described in the specification. Also disclosed are intermediates and processes for their preparation. Further, the process can provide an alternate route for the synthesis of Vernakalant from starting materials that can be readily available.
(FR)L'invention concerne un procédé de préparation d'un composé représenté par la formule I, ou d'un sel pharmaceutiquement acceptable ce celui-ci. Le procédé comprend les étapes consistant à : hydrogéner, en présence d'un catalyseur, un composé représenté par la formule II. Les différents substituants sont tels que décrits dans la spécification. L'invention concerne aussi des produits intermédiaires et des procédés de préparation de ceux-ci. De plus, le procédé constitue un autre moyen de synthèse du vernakalant à partir de matières premières qui sont facilement disponibles.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)