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1. (WO2012038444) LIPASE CONGENERS WITH ENHANCED SUBSTRATE ACCESS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/038444 International Application No.: PCT/EP2011/066353
Publication Date: 29.03.2012 International Filing Date: 20.09.2011
IPC:
C12N 9/20 (2006.01) ,C11D 3/386 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
18
Carboxylic ester hydrolases
20
Triglyceride splitting, e.g. by means of lipase
C CHEMISTRY; METALLURGY
11
ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
D
DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
3
Other compounding ingredients of detergent compositions covered in group C11D1/101
16
Organic compounds
38
Products with no well-defined composition
386
Preparations containing enzymes
Applicants:
BUDISA, Nediljko [HR/DE]; DE (UsOnly)
WILTSCHI, Birgit [AT/DE]; DE (UsOnly)
ROYTER, Marina [DE/DE]; DE (UsOnly)
ANTRANIKIAN, Garabed [DE/DE]; DE (UsOnly)
GROTE, Ralf [DE/DE]; DE (UsOnly)
TECHNISCHE UNIVERSITÄT HAMBURG-HARBURG [DE/DE]; Schwarzenbergstr. 95 21073 Hamburg, DE (AllExceptUS)
TUTECH INNOVATION GMBH [DE/DE]; Harburger Schloßstr. 6-12 21079 Hamburg, DE (AllExceptUS)
Inventors:
BUDISA, Nediljko; DE
WILTSCHI, Birgit; DE
ROYTER, Marina; DE
ANTRANIKIAN, Garabed; DE
GROTE, Ralf; DE
Agent:
UEXKÜLL & STOLBERG; Beselerstr. 4 22607 Hamburg, DE
Priority Data:
10177742.320.09.2010EP
Title (EN) LIPASE CONGENERS WITH ENHANCED SUBSTRATE ACCESS
(FR) CONGÉNÈRES DE LIPASES AYANT UN ACCÈS AU SUBSTRAT AMÉLIORÉ
Abstract:
(EN) The present invention relates to the field of enzyme optimization, and in particular to the optimization of lipase enzymes. Specifically, the invention provides a lipase enzyme which has been modified by the incorporation of one or more non-canonical amino acids to give a lipase congener, said lipase congener having an increased enzymatic activity in an aqueous phase compared to the unmodified enzyme. The invention also relates to the use of such lipase congeners in the soap and detergent industry.
(FR) La présente invention concerne le domaine de l'optimisation d'enzymes et en particulier l'optimisation d'enzymes de type lipases. En particulier, l'invention propose une enzyme de type lipase qui a été modifiée par l'incorporation d'un ou plusieurs acides aminés non canoniques pour donner un congénère de lipase, ledit congénère de lipase ayant une activité enzymatique accrue dans une phase aqueuse par comparaison avec l'enzyme non modifiée. L'invention concerne également l'utilisation de tels congénères de lipases dans l'industrie des savons et des détergents.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)