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1. (WO2012038417) SUBSTITUTED AMINO - BENZOIC ACID DERIVATIVES AS INHIBITORS OF DNA METHYLTRANSFERASES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/038417 International Application No.: PCT/EP2011/066305
Publication Date: 29.03.2012 International Filing Date: 20.09.2011
IPC:
C07D 209/48 (2006.01) ,C07D 311/30 (2006.01) ,C07D 403/06 (2006.01) ,A61K 31/4035 (2006.01) ,A61P 35/00 (2006.01) ,A61P 33/00 (2006.01) ,A61P 25/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
44
Iso-indoles; Hydrogenated iso-indoles
48
with oxygen atoms in positions 1 and 3, e.g. phthalimide
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
04
Benzo [b] pyrans, not hydrogenated in the carbocyclic ring
22
with oxygen or sulfur atoms directly attached in position 4
26
with aromatic rings attached in position 2 or 3
28
with aromatic rings attached in position 2 only
30
not hydrogenated in the hetero ring, e.g. flavones
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
4035
Isoindoles, e.g. phthalimide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33
Antiparasitic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
Applicants:
GUIANVARC'H, Dominique [FR/FR]; FR (UsOnly)
ARIMONDO, Paola [IT/FR]; FR (UsOnly)
SENAMAUD-BEAUFORT, Catherine [FR/FR]; FR (UsOnly)
GRELLIER, Philippe [FR/FR]; FR (UsOnly)
HALBY, Ludovic [FR/FR]; FR (UsOnly)
FERROUD, Clotilde [FR/FR]; FR (UsOnly)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR/FR]; 101, Rue de Tolbiac F-75013 Paris, FR (AllExceptUS)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) [FR/FR]; 3, rue Michel-Ange F-75016 Paris, FR (AllExceptUS)
MUSEUM NATIONAL D'HISTOIRE NATURELLE [FR/FR]; 57, Rue Cuvier F-75005 Paris, FR (AllExceptUS)
CNAM CONSERVATOIRE NATIONAL DES ARTS DES METIERS [FR/FR]; 292, rue Saint Martin F-75141 Paris Cedex 03, FR (AllExceptUS)
Inventors:
GUIANVARC'H, Dominique; FR
ARIMONDO, Paola; FR
SENAMAUD-BEAUFORT, Catherine; FR
GRELLIER, Philippe; FR
HALBY, Ludovic; FR
FERROUD, Clotilde; FR
Agent:
DOMENEGO, Bertrand; Cabinet Lavoix 2, Place d'Estienne d'Orves F-75441 Paris Cedex 09, FR
Priority Data:
10306003.420.09.2010EP
Title (EN) SUBSTITUTED AMINO - BENZOIC ACID DERIVATIVES AS INHIBITORS OF DNA METHYLTRANSFERASES
(FR) DÉRIVÉS D'ACIDE AMINOBENZOÏQUE SUBSTITUÉS COMME INHIBITEURS DE MÉTHYLTRANSFÉRASES DE L'ADN
Abstract:
(EN) The present invention relates to a compound having the following formula (I), wherein : - R1 and R2 are alkyl groups having from 1 to 12 carbon atoms; - X1 is NH or O;- R3, R4, R5 and R6 are in particular H; - X2 is in particular -CH2-; - n is an integer comprised from 2 to 20; and - R is an inhibitor of DNA methyltransferases, or its pharmaceutically acceptable salts, hydrates or hydrated salts or its polymorphic crystalline structures, racemates, diastereomers or enantiomers.
(FR) La présente invention porte sur un composé répondant à la formule (I) suivante, dans laquelle : R1 et R2 représentent des groupes alkyles ayant de 1 à 12 atomes de carbone ; X1 représente NH ou O ; R3, R4, R5 et R6 représentent chacun en particulier H ; X2 représente en particulier -CH2- ; n représente un nombre entier compris entre 2 et 20 ; et R représente un inhibiteur de méthyltransférases de l'ADN, ou ses sels, hydrates ou sels hydratés pharmaceutiquement acceptables ou ses structures cristallines polymorphes, racémates, diastéréoisomères ou énantiomères.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)