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1. (WO2012035039) AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/035039 International Application No.: PCT/EP2011/065892
Publication Date: 22.03.2012 International Filing Date: 14.09.2011
IPC:
A61K 31/429 (2006.01) ,C07D 513/00 (2006.01) ,A61P 29/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
429
condensed with heterocyclic ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
BLENCH, Toby [GB/GB]; GB (UsOnly)
ELLWOOD, Charles [GB/GB]; GB (UsOnly)
GOODACRE, Simon [GB/GB]; GB (UsOnly)
LAI, Yingjie [CA/US]; US (UsOnly)
LIANG, Jun [CN/US]; US (UsOnly)
MACLEOD, Calum [GB/GB]; GB (UsOnly)
MAGNUSON, Steven [CA/US]; US (UsOnly)
TSUI, Vickie [US/US]; US (UsOnly)
WILLIAMS, Karen [GB/GB]; GB (UsOnly)
ZHANG, Birong [US/US]; US (UsOnly)
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
Inventors:
BLENCH, Toby; GB
ELLWOOD, Charles; GB
GOODACRE, Simon; GB
LAI, Yingjie; US
LIANG, Jun; US
MACLEOD, Calum; GB
MAGNUSON, Steven; US
TSUI, Vickie; US
WILLIAMS, Karen; GB
ZHANG, Birong; US
Agent:
SAUER, Frank; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data:
61/383,27315.09.2010US
Title (EN) AZABENZOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
(FR) COMPOSÉS D'AZABENZOTHIAZOLE, COMPOSITIONS ET PROCÉDÉS D'UTILISATION
Abstract:
(EN) Provided are compounds of Formula I, stereoisomers, tautomers, solvates, prodrugs and pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, R4 and R5 are defined herein, a pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, methods of using the compound or composition in therapy, and methods of 5 manufacturing a compound of Formula I.
(FR) L'invention concerne des composés de Formule I, les stéréoisomères, les tautomères, les solvates, les promédicaments et les sels pharmaceutiquement acceptables de ceux-ci, A, X, R1, R2, R4 et R5 étant définis ici, une composition pharmaceutique qui inclut un composé de Formule I et un support, adjuvant ou véhicule pharmaceutiquement acceptable, des procédés d'utilisation du composé ou de la composition en thérapie, et des procédés de fabrication d'un composé de Formule I.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)